Gene Expression

Doberman Pinscher with OCD

i-a6a626faf7acacc3cb8ac8cbf95f776e-doberman.pngIn the wake of my post on selection and variation in dog skull shape, I thought it would be useful to point to this short paper, A canine chromosome 7 locus confers compulsive disorder susceptibility. Here’s the conclusion:

The highly significant association of CCD with the CDH2 region on chromosome 7 is the first genetic locus identified for any animal compulsive disorder, and raises the intriguing possibility that CDH2 and other neuronal adhesion proteins are involved in human compulsive behaviors. A genetic association of cadherins with autism spectrum disorder, which often includes repetitive and compulsive behaviors, has also recently been reported…As little is known about the underlying molecular mechanisms for compulsive behaviors, this discovery could provide a better understanding of disease biology and facilitate development of genetic tests, enabling earlier interventions and even treatment or prevention of compulsive disorders in at-risk canines and humans.

The New York Times has much more.

Citation: Molecular Psychiatry (2010) 15, 8-10; doi:10.1038/mp.2009.111


  1. #1 Alan Kellogg
    January 23, 2010

    Is there a similar genetic locus for OCD for humans, and would testing for it help us develop a treatment for bureaucrats?

  2. #2 blog health
    January 24, 2010

    Because of an editing error, an article on Tuesday about a gene linked to compulsive behavior in dogs misspelled the surname of the actor who played Adrian Monk, the obsessive-compulsive detective in the television series “Monk.” He is Tony Shalhoub, not Shaloub.
    important correction! =)

  3. #3 John Emerson
    January 24, 2010

    Hey, dogs are infantile and often mentally ill. Everyone knows this already.

  4. #4 MediaMentions
    January 31, 2010

    To me, seeing COD be analyzed by both the blogoshpere and the media (ex. is really a very good thing. I know people with the disorder, and any kind of attention means more hope for them, so thanks guys. I do have faith in the dog-human interrelationship, and I too have seen the seeds of success, so to speak.

    Thank you.

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