David Goldstein

Gene Expression

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Show me the data

Update: Also see p-ter at Gene Expression Classic. Follow up on yesterday’s post on the new Dickson et al. paper from David Goldstein’s lab, A New Way to Look for Diseases’ Genetic Roots: The Icelandic gene-hunting firm deCODE genetics, which emerged last week from bankruptcy, has long led in detecting SNPs associated with common disease.…

David Goldstein, a geneticist at Duke, has critiqued the current focus on large-scale genomwide associations before. Now he is taking to the next step, as his group has a paper out which suggests that the reason that association studies have been relatively unfruitful in terms of bang-for-buck is due to the fact that they’re picking…

In search of rare variants

In response to the NEJM issue on personal genomics and the CDCV hypothesis, p-ter offers a proposal: Let’s follow Goldstein’s back-of-the-envelope calculations: assume there are ~100K polymorphisms (assuming Goldstein isn’t making the mistake I attribute to him, this includes polymorphisms both common and rare) that contribute to human height, that we’ve found the ones that…