Disease

Gene Expression

Tag archives for Disease

Africans, disease, history and ecology

Interesting review paper on disease and Sub-Saharan African, Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden: The neglected tropical diseases (NTDs) are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA), and together produce a burden of disease that may be equivalent to…

Addiction is not a “disease” (?)

Recently I listened to the author of Addiction: A Disorder of Choice, Gene M. Heyman, interviewed on the Tom Ashbrook show. A lot of the discussion revolved around the term “disease”, which I can’t really comment on, but a great deal of Heyman’s thesis is grounded in rather conventional behavior genetic insights. In short, a…

Pleiotropy and disease

Two interesting papers, one which relates KITLG and cancer, and another which connects ABCC11 and cancer. These are familiar genes. KITLG has been implicated in depigmentation, both of skin and hair. ABCC11 in earwax form and body odor. If you knock around a gene there is a high probability that you’ll perturb multiple traits. Somethings…

Kambiz of Anthropology.net is back. His first offering reports on a new paper on the evidence for leprosy in India 4,000 years ago. …Lots of hallmarks in human existence occurred during this time period, some being inventions in system of writing, standardized weights and measures, monumental architecture, and trade networks that stretched to Mesopotamia and…

The long tail of human genetics

The New England Journal of Medicine has a series of articles up on the impact of new genomic techniques on medicine, specifically in the domain of pinpointing genetic markers which are correlated with increased risk of a particular disease. David Goldstein has a skeptical take up on the future returns of genomewide association studies, while…

Copy number & common variants

Science News has an interesting piece up, Shared Differences: The architecture of our genomes is anything but basic. The main focus is on genetic variation, the possibility that there might be important information in copy number variance, and that the common disease-common variant hypothesis is dead. At least for complex traits that we’re interested in…