genetic variation

Gene Expression

Tag archives for genetic variation

Dienekes points me to a new paper, European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing Among Diverse European Ethnic Groups. You’ve seen this song & dance before: Population substructure in Japan Population substructure of Mexican Mestizos European population substructure Genetic Map of East Asia The genetics of Fenno-Scandinavia Finns as European…

An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels: Results In this study, genotypes from Human Genome Diversity Panel populations were used to further evaluate a 93 SNP AIM panel, a subset of the 128 AIMS set, for distinguishing continental origins. Using both model-based and relatively model-independent…

In Natural selection of a human gene: FUT2 I referred to a paper, Signals of recent positive selection in a worldwide sample of human populations (see my earlier review). Now the same group has a follow up paper which takes a slightly different tack, The Role of Geography in Human Adaptation: Since the beginning of…

A few months ago I reviewed a paper which examined the various complexities of interpreting signals of natural selection from recently developed genomic tests in response to the avalanche of human sequence data. In the paper, Signals of recent positive selection in a worldwide sample of human populations, the authors state: We find that putatively…

Pleiotropy and disease

Two interesting papers, one which relates KITLG and cancer, and another which connects ABCC11 and cancer. These are familiar genes. KITLG has been implicated in depigmentation, both of skin and hair. ABCC11 in earwax form and body odor. If you knock around a gene there is a high probability that you’ll perturb multiple traits. Somethings…

It is well known that different ethnic groups vary when it comes to diseases such as Type II Diabetes. Or, more specifically they vary in terms of risk, all things equal (if you use an online Type II Diabetes calculator you’ll see immediately as they sometimes have a parameter for ethnicity). American blacks for example…

400-500 years ago in the midst of the Great Dying somewhere the indigenous inhabitants of the New World suffered mortality rates on the order of 90-95%. This was almost certainly due to the facts of evolutionary history; the indigenous peoples had little defense against Eurasian pathogens. A result has been the reality that most of…

Genome-wide Insights into the Patterns and Determinants of Fine-Scale Population Structure in Humans: Studying genomic patterns of human population structure provides important insights into human evolutionary history and the relationship among populations, and it has significant practical implications for disease-gene mapping. Here we describe a principal component (PC)-based approach to studying intracontinental population structure in…

Skin color is not race

One of the peculiarities of American discussion about race is that skin color is assumed to be synonymous with racial distinctions. That is, skin color is not just a trait, but it is the trait which defines between population differences. There’s a reason for this, the skin is the largest organ and it is very…

Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico: Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common…