Genomewide Association
Gene Expression
Tag archives for Genomewide Association
Lactase persistence and BMI – milk does a body fat?
Posted by Razib Khan on March 2, 2010 As you know lactase persistence (LP), which confers the ability to digest lactose sugar as an adult, is an evolutionarily recent development. On the order of 1/3 of the human population exhibits LP, due to a variety of genetic mutations which seem to arise in the cultural background of the domestication of cattle. Some have…
Genome-Wide Associations in Asians
Posted by Razib Khan on February 12, 2010 Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus: In this study, we first conducted a genome-wide association study in a Hong Kong Chinese population, followed by replication in three other cohorts from Mainland China and a cohort from Thailand, which totaled 3,300 Asian patients and 4,200…
Inbred dogs & GWA
Posted by Razib Khan on February 2, 2010 Could be the title of the paper. Anyway, Genome-wide association mapping identifies multiple loci for a canine SLE-related disease complex: …Incidences of specific diseases are elevated in different breeds, indicating that a few genetic risk factors might have accumulated through drift or selective breeding. In this study, a GWA study with 81 affected dogs (cases)…
Show me the data
Posted by Razib Khan on January 26, 2010 Update: Also see p-ter at Gene Expression Classic. Follow up on yesterday’s post on the new Dickson et al. paper from David Goldstein’s lab, A New Way to Look for Diseases’ Genetic Roots: The Icelandic gene-hunting firm deCODE genetics, which emerged last week from bankruptcy, has long led in detecting SNPs associated with common disease.…
Common disease-common variant hypothesis taken down a notch (again)
Posted by Razib Khan on January 25, 2010 David Goldstein, a geneticist at Duke, has critiqued the current focus on large-scale genomwide associations before. Now he is taking to the next step, as his group has a paper out which suggests that the reason that association studies have been relatively unfruitful in terms of bang-for-buck is due to the fact that they’re picking…
Genes which affect female development
Posted by Razib Khan on May 18, 2009 There are several papers and letters in Nature Genetics on the relationship between menarche, menopause, etc. and genetics. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche: We conducted a meta-analysis of genome-wide association data to detect genes influencing age at menarche in 17,510 women. The strongest signal was at 9q31.2 (P…
The genetic architecture of different populations
Posted by Razib Khan on April 28, 2009 Dan MacArthur has a post, Genetics of complex traits in Europeans and East Asians: similarities and differences: With those goals in mind, you can expect to see many more GWAS of non-European populations over the next couple of years, and some explicit comparisons of the differing genetic architecture of complex traits between populations. Exciting times…
Personal genomics, GWA & NEJM
Posted by Razib Khan on April 17, 2009 A much more thorough post by Dan MacArthur on the recent issue of the New England Journal of Medicine & genomics.
The long tail of human genetics
Posted by Razib Khan on April 16, 2009 The New England Journal of Medicine has a series of articles up on the impact of new genomic techniques on medicine, specifically in the domain of pinpointing genetic markers which are correlated with increased risk of a particular disease. David Goldstein has a skeptical take up on the future returns of genomewide association studies, while…