Genomics

Gene Expression

Tag archives for Genomics

I notice that Fortune has a story on personal genomics up, Genetic sequencing gets personal Biotech firm Illumina will sequence your entire genetic code — and throw in a Mac — for $48,000: So far, personalized genomics make up just a small fraction of Illumina’s revenue. High costs keep sequencing out of reach for most…

African genetic structure

I’ve been fine tuning Ubuntu all day with goodies and getting drivers to work right, so I missed this paper on African genetics: Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, 4 African American…

Cattle genetic variation & evolution

There are some papers out on the genome of the domestic cow out right now. ScienceNews has an overview: Two competing research teams have cataloged the “essence of bovinity” found in the DNA of cattle, but not without disagreement on some essential points. Reporting online April 23 in Science and April 24 in Genome Biology,…

Personal genomics, GWA & NEJM

A much more thorough post by Dan MacArthur on the recent issue of the New England Journal of Medicine & genomics.

The long tail of human genetics

The New England Journal of Medicine has a series of articles up on the impact of new genomic techniques on medicine, specifically in the domain of pinpointing genetic markers which are correlated with increased risk of a particular disease. David Goldstein has a skeptical take up on the future returns of genomewide association studies, while…

Copy number & common variants

Science News has an interesting piece up, Shared Differences: The architecture of our genomes is anything but basic. The main focus is on genetic variation, the possibility that there might be important information in copy number variance, and that the common disease-common variant hypothesis is dead. At least for complex traits that we’re interested in…

John Hawks & Daniel MacArthur have already pointed to a new paper in Genome Research, Signals of recent positive selection in a worldwide sample of human populations. As Dan notes, it’s Open Access, so you can read the PDF yourself. That being said, “Just read it!” might be somewhat a tall order if you don’t…

If you read an older work like The History and Geography of Human Genes based on classical genetic markers Sardinia stands out on charts of genetic distance. This is probably due to the fact that Sardinia is an island and gene flow from surrounding regions is relatively limited due to the physical barriers. So the…