Population Substructure

Gene Expression

Tag archives for Population Substructure

A new paper in PLoS, Rapid Assessment of Genetic Ancestry in Populations of Unknown Origin by Genome-Wide Genotyping of Pooled Samples: Many association studies have been published looking for genetic variants contributing to a variety of human traits such as obesity, diabetes, and height. Because the frequency of genetic variants can differ across populations, it…

Lactase persistence results in the ability to break down the lactose sugar in milk as an adult, lactase being the enzyme which breaks down lactose. If one can not digest that sugar, and still consumes milk, then one exhibits the symptoms of lactose intolerance. Originally diagnosed as a disease it has come to light that…

How Columbus was not a seer

A week ago I pointed out that in some visualizations of world wide population variation South Asians & mestizos seem to overlap which each other to a great extent. The reason for this is that both populations can be modeled as admixtures between two separate, but related, populations. Mestizos are the products of pairings between…

Are Chinese subsets of Southeast Asians?

That’s probably the big takeaway of a new paper on the genetics of Asians, a set which includes South Asians, but in the new research mostly focuses on the people of East Asia. In a global context this work is important. The backstory is that there are disagreements about the exact process of the “Out…

According to search engine traffic one of the most popular posts on this weblog has to do with the genetic background of Ashkenazi Jews. That is, those Jews whose ancestors derive from Central & Eastern Europe, and the overwhelming number of Jews in the United States. The genetic origins of this group are fraught with…

About six months ago I had a post up on the Cape Coloureds of South Africa. As a reminder, the Cape Coloureds are a mixed-race population who are the plural majority in the southwestern Cape region of South Africa. Like the white Boers they are a mostly Afrikaans speaking population who are adherents of Reformed…

Population substructure within China

The state of China has 1/5 of humanity within its borders, so it’s genetic structure is of interest. It is obviously important for medical reasons to clarify issues of population structure so that disease susceptibility among the Han is well characterized, in particular with the heightened medical needs of an aging population in the coming…

A new paper in PLoS ONE, Evaluation of Group Genetic Ancestry of Populations from Philadelphia and Dakar in the Context of Sex-Biased Admixture in the Americas, doesn’t add much to what we know. They looked at a several hundred individuals who are self-identified as African American and European American, as well as 49 Senegalese from…

Inferring deep history in genes

When Mendelism reemerged in the early 20th century to become what we term genetics no doubt the early practitioners of the nascent field would have been surprised to see where it went. The centrality of of DNA as the substrate which encodes genetic information in the 1950s opened up molecular biology and led to the…

Dienekes points to a new paper which attempts to quantify the genetic ancestry of South Asian Muslims into indigenous and exogenous components: Islam is the second most practiced religion in India, next to Hinduism. It is still unclear whether the spread of Islam in India has been only a cultural transformation or is associated with…