There is a very interesting discussion going on at Sandwalk regarding adaptationism vs. ... whatever that other thing is that Larry believes in.
But seriously, it is a very interesting discussion that is shaping up as a debate between John Hawks, who wrote a post on this topic recently, and Larry.
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No organism is ever "perfectly adapted" for the environment. Additionally, the founder effect and genetic drift are also very important in population genetics, to assume everything comes down to natural selection is to ignore far too much research.