Clinical trials

Respectful Insolence

Category archives for Clinical trials

So busy was I writing about America’s quack Dr. Mehmet Oz and, of course, the FDA hearing on regulating homeopathy that I didn’t take note of a story that came out the other day examining a study looking at the association between MMR vaccination and autism. More correctly, the study examines the lack of association…

Dr. David Katz is undoubtedly a heavy hitter in the brave new world of “integrative medicine,” a specialty that seeks to “integrate” pseudoscience with science, nonsense, with sense, and quackery with real medicine. In fairness, that’s not the way physicians like Dr. Katz see it. Rather, they see it as “integrating” the “best of both…

Why, oh why, did I look at GreenMedInfo again? You remember GreenMedInfo? It’s yet another wretched hive of scum and quackery, but with a twist. Its proprietor, Sayer Ji, thinks he’s an expert at interpreting the biomedical literature. Unfortunately, as he demonstrates time and time again with depressing regularity, he is nothing of the sort.…

It’s no secret that I don’t have a high opinion of naturopathy. Just enter the word “naturopathy” into the search box of this blog, and you’ll quickly see what I mean. Indeed, when last I mentioned the topic a couple of weeks ago, I was discussing the revelations of Britt Marie Hermes, a former naturopath…

Ancient cancer

As I sat on my couch last night, laptop sitting in front of me, I awaited the Ken Burns adaptation of Siddartha Mukherjee’s excellent book The Emperor of All Maladies into a three part television documentary to air on PBS. I’m not sure whether I’ll blog the show or not, but if I do I’ll…

If there’s one thing that’s become clear to me over the years about acupuncture, it’s that it’s nothing more than a theatrical placebo. Many are the times that I’ve asked: Can we finally just say that acupuncture is nothing more than an elaborate placebo? Most recently, I asked this question in 2012. What science-based medicine…

Yesterday was a very strange day, at least on the Internet. I really should learn to remove Twitter from my iPhone on Wednesdays. Why? Wednesdays tend to be my administrative days. I’m not in clinic seeing patients nor am I in the operating room. That’s why Wednesday tends to be one of the two days…

Now that we’re solidly into 2015, it’s a good time to check in on what the legislative priorities are going to be among various advocates of quackery and “health freedom” (but I repeat myself). There’s a new Republican Congress, and a lot of chairmanships are going to be reshuffled, with various legislators finding themselves in…

So here it is, already a week into 2015. Truth be told, I’m still finding myself having a hard time believing that it’s already 2015, but then I say that about every year in early January. Be that as it may, I’ve already seen one hopeful sign that it could be a decent year when…

Seven years ago I returned to Michigan, where I was born and spent the first quarter century of my life, after an absence of more than 20 years. In the interim, I had done my surgical residency and earned my PhD in Cleveland, a surgical oncology fellowship in Chicago, and worked in New Jersey at…

It should come as a surprise to no one that I’m not exactly a fan of “integrative oncology”—or integrative medicine, or “complementary and alternative medicine” (CAM), or whatever its proponents want to call it these days. After all, I’ve spent nearly ten years writing this blog and nearly seven years running another blog dedicated to…

One thing that happened this week that I didn’t get around to writing about is the 100th anniversary of the birth of Jonas Salk, which was October 28. In the annals of medicine, few people have had as immediate a positive effect as Jonas Salk did when he developed the inactivated polio vaccine (IPV). At…

R.I.P., McKenzie Lowe. Unfortunately, Stanislaw Burzynski was no more able to save you than anyone else, his claims of great success treating pediatric brain tumors notwithstanding: HUDSON — Thirteen-year-old Hudson resident McKenzie Lowe died Friday evening after a 2-year-battle against an aggressive and inoperable brain stem tumor. McKenzie died at 10:27 p.m. in her own…

One of the biggest medical conspiracy theories for a long time has been that there exist out there all sorts of fantastic cures for cancer and other deadly diseases but you can’t have them because (1) “they” don’t want you to know about them (as I like to call it, the Kevin Trudeau approach) and/or…

The antivaccine movement and conspiracy theories go together like beer and Buffalo wings, except that neither are as good as, yes, beer and Buffalo wings. Maybe it’s more like manure and compost. In any case, the antivaccine movement is rife with conspiracy theories. I’ve heard and written about more than I can remember right now,…

Supporters of science-based medicine and keeping pseudoscience out of medicine have a few years to prepare for an onslaught of crappy studies “proving” the value of “integrative” oncology. No doubt at this point you’re wondering just what the heck Orac is talking about. I will tell you. It involves an institution we’ve encountered before and…

These things always seem to happen on Friday. Well, not really. It’s probably just confirmation bias, but it seems that a lot of things I’d like to blog about happen on a Friday. That leaves me the choice of either breaking my unofficial rule not to blog on the weekend or waiting until Monday, when…

Do negative clinical trials change practice?

One of the central themes of this blog from the very beginning is that all medicine, regardless of where it comes from or how it was developed, should be held to a single science-based standard with regards to efficacy, effectiveness, and safety. I tend to focus primarily on “complementary and alternative medicine” (CAM), now more…

Ever since the latest outbreak of Ebola viral disease in West Africa, there has been panic that’s metastasized to the US, even though the risk of a major outbreak here is very low. Unfortunately, whenever there’s panic over a disease, whatever the disease is, there soon follows quackery in response to that panic, from quacks…

Of all the quacks and cranks and purveyors of woo whom I’ve encountered over the years, Deepak Chopra is, without a doubt, one of the most arrogantly obstinate, if not the most arrogantly obstinate. Sure, a quack like Mike Adams wins on sheer obnoxiousness and for the sheer breadth of crankery to which he ascribes,…

Here we go again. If there’s anything that ignites the fevered brains (such as they are) of antivaccine activists, it’s a good seeming conspiracy. Indeed, as we’ve seen before, if they can’t find a legitimate one, they’ll either exaggerate one or make one up out of whole cloth. This week, an “alleged” conspiracy has been…

Clinical trials of magic

I’ll partially apologize here. The reason is that I said I’d be back to business dishing out the Insolence as usual, be it in the form of my usual 2,000 word gems, or slightly shorter, or a lot longer. However, fate intervened. First, there were new developments in the Frank Arguello threat machine. Go back…

As I happened to be out last night at a function for my department, I didn’t have the time necessary to lay out a 2,000 word bit of Insolence. I did, however, have time to note that yet another practitioner unhappy with being criticized over his scientifically questionable treatment, in this case, Dr. Frank Arguello,…

I hadn’t expected to write about this topic again so soon, but then I didn’t expect a major newspaper to have written such a boneheaded editorial about it. In a way, I hate to write this post, because USA TODAY did great things once. There, Liz Szabo wrote the single best science-based report on cancer…

About five weeks ago a month ago, I finally wrote the post I had been promising to write for months before about medical marijuana. At the time, I also promised that there would be follow-up posts. Like Dug the Dog seeing a squirrel, I kept running into other topics that kept me from revisiting the…