Clinical trials

Respectful Insolence

Category archives for Clinical trials

As I contemplated how I wanted to start the blogging week, I thought that I should probably again plug Bob Blaskiewicz’s campaign to provide Dr. Stanislaw Burzynski, the Houston doctor who for the last 35 years has been treating patients diagnosed with advanced stage and terminal cancers with something he calls antineoplastons (ANPs), with a…

I sense another disturbance in the antivaccine Force. Yes, I realize that it was just a couple of days ago that I sensed a previous disturbance rippling through the antivaccine Force. That’s when antivaccinationists brought David Kirby out of mothballs from whatever journalistic slime pit he’s currently residing in to use every trick at his…

More credulous reporting on placebo effects

Now that Trine Tsouderos no longer works for the Chicago Tribune, there aren’t that many reliable generalist medical/science reporters around any more. For example, here in the U.S. there’s Marilyn Marchionne at the AP, Gina Kolata of the New York Times, and then there’s Sharon Begley, who used to be at Newsweek but is now…

Everything Everything gives you cancer Everything Everything gives you cancer There’s no cure, there’s no answer Everything gives you cancer – Joe Jackson I don’t write about nutrition as much as other topics because I’m not as knowledgeable about it as I am about, say, cancer, vaccines, and what constitutes good medical evidence. (I am,…

About a year and a half ago, I applied a heapin’ helpin’ of not-so-Respectful Insolence to a a clueless article about the the “triumph” of New Age medicine. The article channeled the worst fallacies of apologists for alternative medicine. Basically, its whole idea appeared to be that, even if most of “complementary and alternative medicine”…

For all the worship of “translational” research that is currently in vogue, it needs to be remembered that a robust pipeline of basic science progress upon which to base translational research and clinical trials is absolutely essential if progress in medicine is to continue. Without it, progress in SBM will slow and even grind to…

Crank spin versus science on mammography

Sometimes when a study comes out that I’m very interested in blogging about, I don’t get around to it right away. In the blogging biz, this sort of delay is often considered a bad thing, because blogging tends to be very immediate, about being the firstest with the mostest, and the moment to strike and…

A response to the father of a Burzynski patient

If there’s one thing that’s difficult about writing about Stanislaw Burzynski, his highly dubious (nay, bogus) antineoplaston cancer therapy, his “personalized gene-targeted cancer therapy for dummies,” and his shameless rebranding of an orphan drug as a miracle cure for cancer, it’s trying to balance a righteous anger at what he does to desperate cancer patients…

I’ve made no secret of my opinion of a certain “alternative” cancer doctor named Stanislaw Burzynski, MD, PhD, of the infamous Burzynski Clinic. When last we left Burzynski, his propagandist lapdog bootlicker documentary film maker Eric Merola was most unhappy with bloggers like me for having the temerity to tell it like it is when…

As I looked over the ol’ blog last night, I was shocked to realize that I haven’t blogged about the antivaccine movement and its offenses against science in nearly three weeks. That’s right! The last time I did a vaccine post was when I examined a particularly egregiously bad paper from a couple of scientists…

Regular readers probably know that I’m into more than just science, skepticism, and promoting science-based medicine (SBM). (If they’re regular readers of my other, not-so-super-secret other project, they might also realize that they’ve seen this post before elsewhere. I had to stay out late for a work-related event and decided to tart it up and…

As our great Lord Draconis Zeneca promises, besides the fantasies of filthy lucre in the minds of our opponents, there are other rewards to being one of his shills and minions besides getting to blog to my heart’s content about the pseudoscience and quackery that is “alternative” medicine. One of them is that sometimes I…

I’ve been writing about Stanislaw Burzynski again, just yesterday having mentioned a warning letter that the Burzynski Clinic received from the FDA last month. Given Dr. Burzynski’s history of promoting a highly dubious cancer therapy that he calls antineoplastons and administering them to patients under the guise of clinical trials for which he charges patients…

I sometimes think that Stanislaw Burzynski is a lot like the Bloody Mary of folklore, or perhaps Candyman of the famous horror movie—or perhaps like a number of other legends and horror stories—in that all it seems to take for him to show up in the blogosphere again is for me to recite his hame…

Chelation therapy, in my somewhat Insolent opinion, is pure quackery. Unfortunately, it’s also one of the most common quackeries out there, used by a wide variety of practitioners for a wide variety of ailments blamed on “heavy metal toxicity.” Chelation therapy involves using chemicals that can bind to the metal ions and allow them to…

I hate to end the week on a down note, but sometimes it’s necessary. It’s been a while since I’ve written about Stanislaw Burzynski. I’m sure you recall Burzynski. He’s a hero in the alternative medicine world, having been cast as a martyr to The Man (i.e., the FDA and Big Pharma) because of his…

I’d like to publicly thank Dr. John Killen, Jr. I was looking for something to write about yesterday evening, and, just when I was beginning to despair that I might have to do another post on the lunacy that is antivaccine nonsense (even I get tired of taking on antivaccine idiocy, as regular readers know),…

As much as I write about the infiltration of quackademic medicine into medical academia, there is one particular area that is being increasingly invaded by such quackery. It’s an area that you wouldn’t necessarily expect, although anyone who’s read The Men Who Stare at Goats might not be so shocked. Yes, I’m referring to the…

From time to time, I tussle with various animal rights activists online. Over the summer, unfortunately the radical animal rights types, those who think that, at the very least, vandalism is perfectly acceptable in the name of their cause, some of whom think that action up to and including murder of scientists could potentially be…

Our pharma overlords will be displeased…

There’s an oft-quoted saying that’s become a bit of a cliché among skeptics that goes something like this: There are two kinds of medicine: medicine that’s been proven scientifically to work, and medicine that hasn’t. This is then often followed up with a rhetorical question and its answer: What do call “alternative medicine” that’s been…

Overselling preclinical results

As part of my ongoing effort to make sure that I never run out of blogging material, I subscribe to a number of quack e-mail newsletters. In fact, sometimes I think I’ve probably overdone it. Every day, I get several notices and pleas from various wretched hives of scum and quackery, such as NaturalNews.com, Mercola.com,…

A crank attacks the Human Genome Project

The Human Genome Project (HGP) was one of the most massive scientific undertakings in recent years and, from a basic science and technology development standpoint, one of the most productive. The data gained formed the basis of the genomic revolution. And “revolution” is the right word. A mere 12 years after the human genome sequence…

I sense a disturbance in the skeptical blogosphere. It is something that I half-expected, but, even so, it nonetheless somewhat surprised me when it arrived in the form of comments on my blog and e-mails from readers, fellow supporters of science-based medicine, and others asking me what I thought. In a way, it makes me…

The real way to prevent cancer

Long, long ago, seemingly in a galaxy far, far away, I first encountered quackery on the Internet. Because I am a cancer surgeon, naturally I gravitated towards cancer quackery at first. Believe it or not, it was quite some time after that before I started to take an interest in what has become a major…

If there’s one thing I’ve been railing about for the last few years, it’s how scientific and medical studies are reported in the lay press. It seems that hardly a week passes without my having to apply a little Insolence, be it Respectful or not-so-Respectful, to some story or another, usually as a result of…