clinical trials

Tag archives for clinical trials

It is an unquestioned belief among believers in alternative medicine and even just among many people who do not trust conventional medicine that conventional medicine kills. Not only does exaggerating the number of people who die due to medical complications or errors fit in with the world view of people like Mike Adams and Joe…

It’s no secret that I’m a big fan of John Oliver. When my aging body allows me to stay awake late enough on Sunday nights and there’s a new episode on, I’ll almost always be watching. Since starting his own show Last Week Tonight With John Oliver on HBO, Oliver’s become quite the expert at…

It’s no secret that I’m a fan of John Ioannidis. (If you don’t believe me, just type Ioannidis’ name into the blog search box and see how many posts you find.) Over the last couple of decades, Ioannidis has arguably done more to reveal the shortcomings of the medical research enterprise that undergirds our treatments,…

I didn’t think I’d be writing about Stanislaw Burzynski again so soon, but to my surprise a very good article in Newsweek describing cancer quack Stanislaw Burzynski popped up in my Google Alerts yesterday. I hadn’t expected much in the way of news coverage about Burzynski for several months, given that the second half of…

The other day, I suddenly realized that it’s been a long time since I’ve written about the Polish expat doctor in Houston who treats patients with advanced brain cancer with a concoction that he dubbed antineoplastons (ANPs). I’m referring, of course, to Stanislaw Burzynski who, despite the fact that he has no training in medical…

NOTE: Orac is on vacation recharging his Tarial cells and interacting with ion channel scientists, as a good computer should. In the meantime, he is rerunning oldies but goodies, classics, even. (OK, let’s not get carried away.) Here’s one from all the way back in 2007. Notice how, the more things change, the more they…

The approval of new drugs and medical devices is a process fraught with scientific, political, and ethical landmines. Inherent in any such process is an unavoidable conflict between rigorous science and safety on the one side, which tend to slow the process down by requiring large randomized clinical trials that can take years, versus forces…

When I wrote yesterday about the cruel sham that is “right-to-try,” , one criticism (among many) that I made of these misguided, profoundly patient-unfriendly laws was that I have as yet been unable to find a single example of a patient who has managed to obtain access to an experimental therapeutic through such a law,…

Last year, I did several posts on what I consider to be a profoundly misguided and potentially harmful type of law known as “right-to-try.” Beginning about a year and a half ago, promoted by the libertarian think tank known as the Goldwater Institute, right-to-try laws began popping up in state legislatures. I wrote about how…

R.I.P., McKenzie Lowe. Unfortunately, Stanislaw Burzynski was no more able to save you than anyone else, his claims of great success treating pediatric brain tumors notwithstanding: HUDSON — Thirteen-year-old Hudson resident McKenzie Lowe died Friday evening after a 2-year-battle against an aggressive and inoperable brain stem tumor. McKenzie died at 10:27 p.m. in her own…

One of the biggest medical conspiracy theories for a long time has been that there exist out there all sorts of fantastic cures for cancer and other deadly diseases but you can’t have them because (1) “they” don’t want you to know about them (as I like to call it, the Kevin Trudeau approach) and/or…

Do negative clinical trials change practice?

One of the central themes of this blog from the very beginning is that all medicine, regardless of where it comes from or how it was developed, should be held to a single science-based standard with regards to efficacy, effectiveness, and safety. I tend to focus primarily on “complementary and alternative medicine” (CAM), now more…

Clinical trials of magic

I’ll partially apologize here. The reason is that I said I’d be back to business dishing out the Insolence as usual, be it in the form of my usual 2,000 word gems, or slightly shorter, or a lot longer. However, fate intervened. First, there were new developments in the Frank Arguello threat machine. Go back…

I hadn’t expected to write about this topic again so soon, but then I didn’t expect a major newspaper to have written such a boneheaded editorial about it. In a way, I hate to write this post, because USA TODAY did great things once. There, Liz Szabo wrote the single best science-based report on cancer…

There are times when supporting science-based health policy and opposing health policies that sound compassionate but are not are easily portrayed as though I’m opposing mom, apple pie, and the American flag. One such type of misguided policy that I’ve opposed is a category of bills that have been finding their way into state legislatures…

There’s a point I feel that I have have to make briefly as I begin this post. Basically, this might look familiar, but given that I was at TAM Wednesday through Sunday, I didn’t have time to produce two separate posts, and this is important enough to be distributed as widely as possible. In any…

Our regularly scheduled post will go live later this morning. In the meantime, this is a public service announcement…with GUITAR! (Oh, wait.) As you recall, last week, the FDA inexplicably decided to lift the partial clinical hold on Stanislaw Burzynski’s bogus clinical trials of antineoplastons, which he’s used since the 1990s as a pretext to…

Placebo effects in surgery

Although I’m a translational researcher, I’m also a surgeon. That was my first and primary training and only later did I decide to get my PhD during my residency, when the opportunity to do so with a decent stipend presented itself. From my perspective, clinical research in surgery is difficult, arguably more difficult than it…

Over the years, the criticism of “evidence-based medicine” (EBM) that I have repeated here and that I and others have repeated at my not-so-super-secret other blog is that its levels of evidence relegate basic science considerations to the lowest level evidence and elevate randomized clinical trial evidence to the highest rung, in essence fetishizing it…

Rare is the occasion when I disagree significantly with my collaborator Steve Novella, but this is one of those times. It’s a measure of how much we agree on most things that, even in this case, I don’t completely disagree with him. But, hey, it happens. I’m referring to Steve’s post yesterday in which he…

The last couple of weeks, I’ve made allusions to the “Bat Signal” (or, as I called it, the “Cancer Signal,” although that’s a horrible name and I need to think of a better one). Basically, when Bat Cancer Signal goes up (hey, I like that one better, but do bats get cancer?), it means that…

I don’t know if it’s a sign that I’ve arrived as being a bit more influential than just a blogger or just dumb luck when reporters start sending me things, but I’ll take it. It’s like blog fodder being served to me on the proverbial silver platter. Unfortunately, as a result of receiving a press…

There are certain things that can happen that are the equivalent of the Bat Signal to me; that is, if you can swallow the idea of me being in any way like Bruce Wayne. Call them the Cancer Signal, if you will. When I see the Cancer Signal, I know that I have to head…

I was very pleased last Friday, very pleased indeed. Given the normal subject matter of this blog, in which we face a seemingly unrelenting infiltration of pseudoscience and quackery into even the most hallowed halls of academic medicine, against which we seem to be fighting a mostly losing battle, having an opportunity to see such…

It’s been a while since I’ve written about Stanislaw Burzynski, the Houston cancer doctor who inexplicably has been permitted to continue to administer an unproven cancer treatment to children with deadly brain cancers for nearly 37 years now. Beginning in 1977, when he left Baylor College of Medicine and opened up the Burzynski Clinic, Burzynski…