Image of a cynomolgus macaque. Image credit: iStockphoto/Anna Yu


Researchers at Amgen in British Columbia and California have developed an antibody called mimAb1 that mimics the properties of fibroblast growth factor 21 (FGF21). Having a role in regulating fat and glucose metabolism as well as body weight made this particular growth factor a target for the treatment of obesity and diabetes. When administered to obese cynomolgus monkeys, the new antibody promoted significant weight loss as well as decreases in circulating insulin and glucose concentrations during a tolerance test, suggesting that it has beneficial effects in the treatment of diabetes as well. The researchers hope that these findings will lead to clinical trials testing the effects of the antibody in humans.


I. N. Foltz, S. Hu, C. King, X. Wu, C. Yang, W. Wang, J. Weiszmann, J. Stevens, J. S. Chen, N. Nuanmanee, J. Gupte, R. Komorowski, L. Sekirov, T. Hager, T. Arora, H. Ge, H. Baribault, F. Wang, J. Sheng, M. Karow, M. Wang, Y. Luo, W. McKeehan, Z. Wang, M. M. Véniant, Y. Li, Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the βKlotho/FGFR1c Receptor Complex. Sci. Transl. Med. 4, 162ra153 (2012).


  1. #1 Krissie
    December 1, 2012

    This is interesting news indeed! Obesity and diabetes rob people of living full, healthy lives. I hope that this new antibody will eventually be able to help fight these conditions in humans.

    Thanks for sharing!

  2. #2 Gerson Va
    December 3, 2012

    Interesting. I would also love if this could later be of great help to humans.

  3. #3 Weight loss, Weight loss and, Weight loss be
    January 6, 2013

    That’s the way to attain a healthy life style!