Life Lines

Additional highlights from the Comparative Physiology posters presented at the 2014 Experimental Biology conference in San Diego, CA:

TA White, G Evans, GC Verzosa, T Pirtskhalava, T Tchkonia, JD Miller, JL Kirkland, and NK LeBrasseur. “Aging and cellular senescence and disease: The influence of diet and exercise”
Not surprisingly, mice consuming a fast food diet for 5 months gain weight, have impaired glucose tolerance, and blood pressure problems. If they are given a running wheel to use voluntarily, the effects on weight and cardiac function can be prevented. In addition, markers of inflammation that were seen to increase with ingestion of a fast food diet are also decreased with exercise. Maybe I should invest in a running wheel…

Image from http://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=118659

Image from http://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=118659

JM York, JU Meir, J Willy, B Chua, LA Hawkes, CM Bishop, PJ Butler, P Frappell, WK Milsom. “Cardiorespiratory and metabolic changes during hypoxic flight in bar-headed geese”
I have always been fascinated by animals that seem to thrive in extreme environments, like the bar-headed geese that fly over the Himalayas twice a year. Using wind tunnels, this research team (including newly selected astronaut Dr. Jessica Meir) discovered that under hypoxic conditions that mimic high altitude flight, bar-headed geese are able to match oxygen supply with oxygen demand by increasing their heart rates and the oxygen pulse.

H Onken, M Bassous, DF Moffett, C Corbo. “The alkaline anterior midgut of larval mosquitoes as a barrier for microorganisms”
Research by Onken et al. shows that the high pH in the midgut of mosquito larvae creates a barrier for bacteria. As if they needed more survival tactics.

J Margotta, MM Elekonich, SP Roberts. “Understanding how honey bee flight and senescence are connected through oxidative stress”
This was an interesting study that showed how the high metabolic activity of flight may cause oxidative stress and accelerate aging in honey bees.

S Cooper, D Howard, T Koch, X Lin, N Johnston, K Dobbs, M Zuberbuehler, A Cooper, C Lamont, S Mortimer, S Hying, K Bernhardt, S Sell, L Nelson, J Hawes, H Willems, L Morgan, G Macapugay, C Krus, M Bowman, S Lloyd. “Platelet levels and activity are decreased in hibernating 13-lined ground squirrels which may prevent venous thromboembolism”
This is something that I have wondered about. How do hibernating animals prevent blood clots when their blood flow is so low? One mechanism is through decreased production and activity of platelets, which promote the development of blood clots.

Image of Dr. Beutler from http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/beutler-facts.html

Image of Dr. Beutler from http://www.nobelprize.org/nobel_prizes/medicine/laureates/2011/beutler-facts.html

The American Physiological Society (APS) closed the meeting last night with a lecture from Dr. Bruce A. Beutler, 2011 Nobel Prize winner in Physiology or Medicine for his work on understanding the innate immune system. Dr. Beutler is from the Univ. Texas, Southwestern Medical Center and spoke about “Monitored Mutagenesis of the Mouse Genome to Identify Proteins with Essential Immune Functions.”

His session was followed by the closing party that featured a band of gastrointestinal physiologists called “GI Distress.” Seriously, I am not sure that it gets much cuter than that! You can check them out in this YouTube video uploaded by UMass Medical School. Incidentally, the recipient of this year’s August Krogh Distinguished Lectureship is also one of the back up singers for the band.

Comments

  1. #1 14111838
    Pretoria
    May 3, 2014

    Wow! I have always known that fast food have a negative impact on one’s health but little did I know that when you exercise you are preventing the effects of fast food on weight and cardiac function. I always thought that exercise is only for weight loss and being “in shape”. If I may ask do humans relate that much to mice since the experiment was performed on mice?

  2. #2 14111838 (Nomcebo Tshabalala)
    Hatfield
    May 4, 2014

    this is very intriguing.