Check out this new YouTube video describing a new study aimed at discovering how elephants resist developing cancer:

Comments

  1. #1 Daniel.Corcos
    https://www.researchgate.net/profile/Daniel_Corcos2
    October 18, 2015

    I am not quite sure that this study can result in any kind of treatment, but this as been proposed before:
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693304/

  2. #2 Elaine
    October 22, 2015

    I believe the study will change people’s life. Elephants can be helpful in cancer treatment. Impressed! Maybe cancer deaths can be improved effectively in future.

    http://www.creative-peptides.com/blog/index.php/cancer-deaths-could-be-improved-by-2050/

  3. #3 Daniel Corcos
    France
    October 24, 2015

    Soon, an elephant in the chemo room?
    I am disappointed that the media pay so much attention to silly proposals at the end of an experimental study or to university press releases aimed at promoting a basic research lab. There are much more realistic approaches taking into account the physiology of the cancer cells, which may lead to treatment, and do not receive such publicity.
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799276/

  4. #4 Malvy Claude Paul
    Villejuif, France
    November 8, 2015

    There is a difference between manipulated
    mice and animals naturally selected like
    elephants. Animal expermentation for
    cancer research is important but studies
    of natural cancers in animals is also
    important. There was also ( may be still there
    is to day ) research on sharks which have no
    cancers. There are many anti-oncogenes
    but it might be that TP53 remains therefore
    one of the most attractive for gene therapy
    In the future, vectors for gene therapy will I
    suppose and I hope.
    improve. Would it be then silly to treat people
    with a high risk of cancer occurence ( for
    instance people having being exposed to
    high doses of carcinogenic agents) with
    a TP 53 gene therapy ?

  5. #5 Daniel Corcos
    https://www.researchgate.net/profile/Daniel_Corcos2/
    November 12, 2015

    Malvy Claude Paul
    “Would it be then silly to treat people
    with a high risk of cancer occurence ( for
    instance people having being exposed to
    high doses of carcinogenic agents) with
    a TP 53 gene therapy ?”
    My answer would be: yes it would be silly. Because it is not sure that it would be efficient, because there is a risk of insertional mutagenesis and because gene therapy efficiency is not 100%. This means that cells no efficiently transfected could be led to proliferate as a side effect of gene therapy, and it will counteract the beneficial effect.

  6. #6 Malvy Claude Paul
    Villejuif , France
    November 14, 2015

    When I mean vectors will improve, I
    mean that their rate of transfection cell efficiency
    will be very high and that they will
    have a very high rate of targeted ( non random) insertion
    in DNA. Of course the animal models will
    be required to test the benefit/risk ratio
    before any clinical trial. There is no treatment
    without side effects. With actual chemotherapy
    it is known that secondary cancers can be
    induced by chemotherapy. This does not
    prevent of course to use chemotherapy to
    treat patients.

  7. #7 Craig Thomas
    November 22, 2015

    Here’s an Elephant getting The Treatment: