diabetes

Tag archives for diabetes

Malnutrition during pregnancy is a major global health issue that leads to restricted growth of developing fetuses making them more prone to death and disease. In fact, babies born from poorly nourished mothers are more likely to develop obesity, metabolic syndrome and cardiovascular disease as adults. Researchers from the University of Colorado and University of Texas Health…

Sheep as models for diabetes

Insulin is a major hormone responsible for regulating blood sugar. Its main function is to lower sugar by increasing glucose uptake into muscle and fat cells. Insulin resistance is the hallmark of type 2 diabetes and occurs when tissues in the body are not able to respond to insulin resulting in sustained elevations in blood sugar,…

2015 Experimental Biology- Day 2

I was very impressed by the graduate and undergraduate students who presented their research at the Scholander poster competition sponsored by the Comparative and Evolutionary Physiology section of the American Physiological Society this afternoon. I am sure the winner of the competition will be very difficult to select. Some highlights included: Bridget Martinez, graduate student at the University of California…

A new study published in  AJP-Regulatory, Integrative and Comparative Physiology suggests that electroacupuncture to the abdominal region may prevent increases in blood sugar concentrations after a meal by affecting insulin sensitivity and circulating free fatty acid concentrations.  Granted this is not comparative physiology research, I find it interesting that electrical stimulation can have such a large impact…

Only mammals express RAGE

RAGE stands for “receptor for advanced glycation end-products”, also known as “AGER”, and new research shows that it first appeared in mammals (Sessa et al., 2014). Despite the name, the receptor also binds other signaling molecules such as HMGB1, S100 proteins, beta-amyloid, phosphatidylserine, among others (Xie et al., 2013). RAGE is reportedly involved in diabetes,…

I was so excited to see a story featuring grizzly bears (Ursus arctos horribilis) in the Wall Street Journal yesterday. The article was about how Dr. Kevin Corbit at Amgen Inc. is studying grizzly bears in the Bear Center at Washington State University to learn more about obesity. The 12 animals living in the facility…

A new study from Science Translational Medicine (DOI:10.1126/scitranslmed.3006534) presents data showing that tauroursodeoxycholic acid (TUDCA), a compound isolated from the bile of bears, may actually slow the development of type 1 diabetes (in mice at least). It is thought to work by reducing stress responses from the endoplasmic reticulum in the insulin-producing beta cells of…

Experimental Biology – Sunday

The Comparative and Evolutionary Physiology section held their Scholander Poster competition for young comparative physiologists today! It was exciting to see all of the students present their work. Here are some of the highlights: Raffaele Pilla, Dominic P, D’Agostino, Carol S. Landon, and Jay B. Dean from Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL.…

Diabetes is characterized by high blood sugar. The cause of high blood sugar differs for people with type 1 versus type 2 diabetes. For type 1 diabetics, the pancreas produces little or no insulin, the hormone responsible for lowering blood sugar. For type 2 diabetics, tissues in the body are not responsive to insulin, termed…

    Researchers at Amgen in British Columbia and California have developed an antibody called mimAb1 that mimics the properties of fibroblast growth factor 21 (FGF21). Having a role in regulating fat and glucose metabolism as well as body weight made this particular growth factor a target for the treatment of obesity and diabetes. When administered to…