diabetes

Tag archives for diabetes

A new study published in  AJP-Regulatory, Integrative and Comparative Physiology suggests that electroacupuncture to the abdominal region may prevent increases in blood sugar concentrations after a meal by affecting insulin sensitivity and circulating free fatty acid concentrations.  Granted this is not comparative physiology research, I find it interesting that electrical stimulation can have such a large impact…

Only mammals express RAGE

RAGE stands for “receptor for advanced glycation end-products”, also known as “AGER”, and new research shows that it first appeared in mammals (Sessa et al., 2014). Despite the name, the receptor also binds other signaling molecules such as HMGB1, S100 proteins, beta-amyloid, phosphatidylserine, among others (Xie et al., 2013). RAGE is reportedly involved in diabetes,…

I was so excited to see a story featuring grizzly bears (Ursus arctos horribilis) in the Wall Street Journal yesterday. The article was about how Dr. Kevin Corbit at Amgen Inc. is studying grizzly bears in the Bear Center at Washington State University to learn more about obesity. The 12 animals living in the facility…

A new study from Science Translational Medicine (DOI:10.1126/scitranslmed.3006534) presents data showing that tauroursodeoxycholic acid (TUDCA), a compound isolated from the bile of bears, may actually slow the development of type 1 diabetes (in mice at least). It is thought to work by reducing stress responses from the endoplasmic reticulum in the insulin-producing beta cells of…

Experimental Biology – Sunday

The Comparative and Evolutionary Physiology section held their Scholander Poster competition for young comparative physiologists today! It was exciting to see all of the students present their work. Here are some of the highlights: Raffaele Pilla, Dominic P, D’Agostino, Carol S. Landon, and Jay B. Dean from Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL.…

Diabetes is characterized by high blood sugar. The cause of high blood sugar differs for people with type 1 versus type 2 diabetes. For type 1 diabetics, the pancreas produces little or no insulin, the hormone responsible for lowering blood sugar. For type 2 diabetics, tissues in the body are not responsive to insulin, termed…

    Researchers at Amgen in British Columbia and California have developed an antibody called mimAb1 that mimics the properties of fibroblast growth factor 21 (FGF21). Having a role in regulating fat and glucose metabolism as well as body weight made this particular growth factor a target for the treatment of obesity and diabetes. When administered to…

Could camels hold secret to survival?

Bactrian camels thrive in conditions considered harsh by many standards: very dry, cold, high elevations. Researchers now suspect their physiological adaptations of high blood sugar, high salt diets, and increased body fat may have evolved to help the animals cope with their environment. For humans, those symptoms could lead to heart disease, but for the Bactrian…