insulin

Tag archives for insulin

Sheep as models for diabetes

Insulin is a major hormone responsible for regulating blood sugar. Its main function is to lower sugar by increasing glucose uptake into muscle and fat cells. Insulin resistance is the hallmark of type 2 diabetes and occurs when tissues in the body are not able to respond to insulin resulting in sustained elevations in blood sugar,…

2015 Experimental Biology- Day 2

I was very impressed by the graduate and undergraduate students who presented their research at the Scholander poster competition sponsored by the Comparative and Evolutionary Physiology section of the American Physiological Society this afternoon. I am sure the winner of the competition will be very difficult to select. Some highlights included: Bridget Martinez, graduate student at the University of California…

I was so excited to see a story featuring grizzly bears (Ursus arctos horribilis) in the Wall Street Journal yesterday. The article was about how Dr. Kevin Corbit at Amgen Inc. is studying grizzly bears in the Bear Center at Washington State University to learn more about obesity. The 12 animals living in the facility…

A new study from Science Translational Medicine (DOI:10.1126/scitranslmed.3006534) presents data showing that tauroursodeoxycholic acid (TUDCA), a compound isolated from the bile of bears, may actually slow the development of type 1 diabetes (in mice at least). It is thought to work by reducing stress responses from the endoplasmic reticulum in the insulin-producing beta cells of…

Diabetes is characterized by high blood sugar. The cause of high blood sugar differs for people with type 1 versus type 2 diabetes. For type 1 diabetics, the pancreas produces little or no insulin, the hormone responsible for lowering blood sugar. For type 2 diabetics, tissues in the body are not responsive to insulin, termed…