Mike the Mad Biologist

I’ve recently written a couple of posts about how evolution is used in medicine. Randolph Nesse and Stephen Stearns in Evolutionary Applications have written an article about evolutionary medicine. Here’s one part that provides some additional examples (italics mine):

Some of the most useful applications of evolution often do not use evolutionary theory directly; instead they use technologies developed by evolutionary biologists. In particular, methods for reconstructing phylogenies are being applied to genetic data with very practical results. HIV is especially susceptible to such methods because its fast-accumulating mutations create finely detailed phylogenies. For instance, certain cases of HIV could be traced back to a specific Florida dentist (Ciesielski et al. 1992). Phylogenetic analysis also was used to falsify the hypothesis that HIV was introduced into Africa via polio vaccine (Weiss 2001). The SARS epidemic was traced quickly to a corona virus similar to one endemic in bats (Li et al. 2004; Skowronski et al. 2005).

Tracing pathogen phylogenies can be very useful. Influenza phylogenies suggest which strains are likely to spread in future epidemics (Bush et al. 1999; Ghedin et al. 2005; Smith 2006), information vital to decisions about vaccine design. The current H5N1 avian influenza pandemic appears to have originated via reassortment between avian influenza strains circulating in eastern Asia (Li et al. 2004).

Public health now uses such methods routinely to trace the source of contaminated foods [Mad Biologist: Ahem]. These phylogenetic methods have a remarkable reach, back even into prehistory. For instance, the complete genome sequence of the severely pathogenic Shigella flexneri reveals that it is phylogenetically indistinguishable from the Escherichia coli that lives normally in the human gut (Wei et al. 2003). The difference seems to be in a few virulence factors that result in substantially different ecological niches for the two organisms [Mad Biologist: I told you].

Technologies for tracing phylogenies have ready application to antibiotic resistance and to pathogen evolution in general. They are particularly powerful in revealing the origins of emerging diseases. For example, HIV1 originated in chimpanzees in Central Africa, and HIV2 originated in sooty mangabeys in West Africa (Heeney et al. 2006). Importantly, these species do not develop AIDS.

Phylogenetic methods have also found recent applications in cancer research and treatment. Cell lines differentiate as mutations accumulate, and the genetic differences make it possible to trace the sequence. Two tumors that are histologically identical can have very different proteonomic signatures that make it possible to assess the level of cellular differentiation (Abu-Asab et al. 2006). Whether a tumor is all derived from the one line of cells, or from different origins arising during the tumor’s growth may also be an important indicator (Merlo et al. 2006; Frank 2007).

Researchers in every area of medicine use phylogenetic methods to analyze genetic data. Sometimes they are used in conjunction with evolutionary theory, but they are also used independently to construct phylogenies with new applications in an era of genetic medicine. Doctors who understand these phylogenetic methods and the evolutionary biology behind them will be better prepared to judge the significance of research findings such as those summarized above.

The article is actually accessible to non-scientists. I recommend reading it.

Cited article: Randolph M. Nesse, Stephen C. Stearns (2008) The great opportunity: Evolutionary applications to medicine and public health
Evolutionary Applications 1 (1) , 28-48 doi:10.1111/j.1752-4571.2007.00006.x

Comments

  1. #1 Sandra Porter
    April 8, 2008

    This is a great post Mike!

    But – when I click the link to the article, I get an error message.

  2. #2 Ian
    April 8, 2008

    Someone needs to point Egnor towards this!

  3. #3 DrA
    April 8, 2008

    Thanks for the tip on the Neese and Stearns article, and several more in the same issue (open access) were equally interesting. Now if I only could get our microbiologist and cell biologists to grasp that ecology and evolution are important concepts for pre-med education.

  4. #4 BWV
    April 8, 2008

    But that is just micro-evolution!

    (just kidding – but I know from experience any evidence like this can just be dismissed by creationists with this tactic)

  5. #5 NP
    April 9, 2008

    Thanks for alerting us to this paper. Nonetheless, BWV correctly points out that creationists (cdesign proponentsists included) have a ready-made “frame” to dismiss the importance of learning evolution.

  6. #6 Mike the Mad Biologist
    April 9, 2008

    BWV, NP,

    In this case, but there are other instances described in the paper that use interspecies comparisons (malaria).

    Then again, creationists will find a way to bullshit around that too…

  7. #7 SJC
    April 16, 2008

    Can we just tell the creationists that if they don’t believe evolutionary theory applies, then they can do without medicine?

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  15. #16 son projeler
    May 20, 2011

    In this case, but there are other instances described in the paper that use interspecies comparisons (malaria).

  16. #17 proje haberleri
    May 20, 2011

    I know from experience any evidence like this can just be dismissed by creationists with this tactic…

  17. Thanks for the tip on the Neese and Stearns article, and several more in the same issue (open access) were equally interesting. Now if I only could get our microbiologist and cell biologists to grasp that ecology and evolution are important concepts for pre-med education.

  18. #19 konutfirsatlari
    May 20, 2011

    Thanks for alerting us to this paper. Nonetheless, BWV correctly points out that creationists (cdesign proponentsists included) have a ready-made “frame” to dismiss the importance of learning evolution.

  19. #20 emlak haberci
    May 20, 2011

    from experience any evidence like this can just be dismissed by creationists with this tactic…Can we just tell the creationists that if they don’t believe evolutionary theory applies, then they can do without medicine?

  20. #21 emlak haberci
    August 24, 2011

    I know from experience any evidence like this can just be dismissed by creationists with this tactic…

  21. #22 konut haber
    August 24, 2011

    Thanks for the tip on the Neese and Stearns article, and several more in the same issue (open access) were equally interesting

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