Publishing in Chemistry & Biology Truman et al. have identified a single amino acid substitution in the active site of the protein Cep15, which is part of the glycopeptide antibiotic chloroeremomycin biosynthetic machinery in Amycolatopsis orientalis, that abolishes its catalytic activity. Reversing a point mutation in the cep15 gene produced a functional enzyme. This finding represents the first time that the function of a bacterial pseudogene has been restored by a point mutation.
But TEH MUTATION IZ EVUL!
Actually, I wonder if this mutation that deactivated the enzyme is adaptive in a different context, or if it arose via drift. Now, that’s something interesting to ponder.