Recently, Newsweek published an article by Sharon Begley that claimed that the conflict between high-profile publication and quick release of medically-important data has led to delays in medical advancements (ScienceBlogling Orac takes down her particular example). But Begley is confusing a symptom, publication practices, with a much larger problem: incentives.
What do I mean by incentives?
Last week, I described how the data release policies of large and small sequencing centers differ due to distinct funding incentives: the larger centers are paid to rapidly produce lots of high quality data, while the smaller centers are paid to produce high-quality publications.
A similar dynamic is at work here. Regarding the specifics of publication, you do want to publish in a high-profile journal. That’s not just due to careerism: if you want to keep your research going (and if you think your research could lead to medical treatments, that’s a perfectly decent reason to do so), then you need high-profile publications. Until NIH (and other government agencies) change that reward scheme, this will keep happening.
But there’s a larger picture too. Begley decries the dearth of translational research. Well, NIH doesn’t really focus on translational (i.e., more applied) research: it focuses on basic research. It’s not just NIH officials too–NIH relies on the expertise of outside reviewers who are, for the most part, oriented towards basic research*.
I’ve seen this phenomenon with antibiotic resistance. Most of the research on antibiotic research deals with the basic biology of antibiotic resistance and antibiotic resistant organisms. This is a good and important thing, since understanding this will, in the long term, lead to interventions. If you ask me, what, in the short term, would reduce the spread of resistance, it would be to implement rigorous, scientifically-validated infection control measures (WASH YOUR DAMN HANDS!!!).
But NIH doesn’t do this sort of thing. This why AHRQ was created. Of course, the NIH budget for antibiotic resistance (~$800 million) is double the entire budget of AHRQ, but that’s a separate issue.
This one example of a larger issue: if we want researchers to prioritize translational research, then that’s where the money needs to be. Trust me, if the money is there, the high-profile journals will follow.
It’s all about incentives.
*If NIH brought in lots of reviewers from industry, they would then be viewed as captive to industry, of course….