Mike the Mad Biologist

The success of a European MRSA surveillance network shows just how stupid, foolish, and short-sighted the Obama Administration’s decision to cut CDC antimicrobial resistance surveillance is. But let’s turn this frown upside down campers, and look at the really cool website the European Staphylococcal Reference Laboratory Working Group set up.

Each of the Google Map pins represents a different surveillance laboratory. If you click on the pin, it tells you how many Staphylococcus aureus (‘staph’) isolates have been typed. You can then click the “view spa types” link. spa is a highly variable genetic locus* that is used to tell S. aureus isolates apart. The site then shows you the number of different spa types found in at that site and how often that type is found at that site and throughout Europe.

What’s really cool (to me, anyway) is that the site will show you where else in Europe that site is found, how many isolates were found at other sites, the mortality due to that spa type, the frequency of methicillin resistance in that spa type, and the age distribution of patients infected with that spa type. You can also click on the spa type itself and find out the details of each individual S. aureus isolate.

So other than the ‘gee whiz’ factor, what good is this system? (Other than keeping microbiologists and computer programmers off the streets….). Well, here’s a summary of what this network found so far:

These findings provide the first representative snapshot of the genetic population structure of S. aureus across Europe. Because the researchers used spa typing, which analyzes only a small region of one gene, and characterized only 3,000 isolates, analysis of other parts of the S. aureus genome in more isolates is now needed to build a complete portrait of the geographical abundance of the S. aureus clones that cause invasive infections in Europe. However, the finding that MRSA spa types occur mainly in geographical clusters has important implications for the control of MRSA, because it indicates that a limited number of clones are spreading within health care networks, which means that MRSA is mainly spread by patients who are repeatedly admitted to different hospitals. Control efforts aimed at interrupting this spread within and between health care institutions may be feasible and ultimately successful, suggest the researchers, and should be strongly encouraged. In addition, this study shows how, by sharing typing results on a Web-based platform, an international surveillance network can provide clinicians and infection control teams with crucial information about the dynamics of pathogens such as S. aureus, including early warnings about emerging virulent clones.

We actually now have a strategy for limiting or even stopping the spread of MRSA in Europe: rigorously screen, or even prospectively isolate patients who visit multiple medical facilities regularly.

This is why surveillance matters.

*There are other typing methods, and as the PLoS Medicine editors note, they need to be applied to these isolates too.

Cited articles: Lowy FD (2010) Mapping the Distribution of Invasive Staphylococcus aureus across Europe. PLoS Med 7(1): e1000205. doi:10.1371/journal.pmed.1000205

Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, et al. (2010) Geographic Distribution of Staphylococcus aureus Causing Invasive Infections in Europe: A Molecular-Epidemiological Analysis. PLoS Med 7(1): e1000215. doi:10.1371/journal.pmed.1000215

Comments

  1. #1 maryn
    February 9, 2010

    Excellent. Been meaning to get to this paper…

  2. #2 addie
    February 9, 2010

    CBS tonight on antibiotics and agribusiness:

    Meat industry groups are bracing for consumer backlash from a much-anticipated CBS Evening News series on antibiotic use in food animal production, scheduled to air this week after experiencing several delays.

    The series, scheduled to air Feb. 9 and 10 (6:30 p.m. EST), is widely expected to be critical of animal antibiotic use, which has led industry groups to preemptively lobby and organize to prevent momentum for bills before Congress that would curb antibiotic use in agriculture.

    The National Cattlemen’s Beef Association held a briefing on Capitol Hill last week to educate staffers and rally opposition to the bills. Several other industry groups released talking points and action alerts before the series was scheduled to air last week.

    “You need to contact your lawmakers and urge them not to support H.R. 1549/S. 619,” the National Pork Producers Council told its members, according to Meatingplace last week. “Reiterate to them that there’s no proof that antibiotic use on farms significantly increases resistant bacteria in humans and no indication that this legislation will slow the development of resistant bugs.”

    Most consumer and public health groups disagree with the industry message. According to to a recent Pew Campaign on Human Health and Industrial Farming report, “A key contributor to the rise of antibiotic-resistant bacteria is the overuse of drugs on industrial farms.”

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    Most consumer and public health groups disagree with the industry message. According to to a recent Pew Campaign on Human Health and Industrial Farming report, “A key contrib

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    Most consumer and public health groups disagree with the industry message. According to to a recent Pew Campaign on Human Health and Industrial Farming report, “A key contrib

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