KPC

Mike the Mad Biologist

Category archives for KPC

In this story about the use of rapid genomic sequencing to monitor a hospital outbreak of multi-drug resistant Klebsiella pneumoniae (more details here), this end bit is interesting (italics mine): “In the E. coli outbreak, we had enough E. coli reference strains and knew enough about E. coli biology to quickly identify a set of…

If you haven’t heard, there’s a new antibiotic resistance gene, NDM-1, which stands for New Delhi metallo-beta-lactamase-1. This gene has been found in Gram-negative Enterobacteriaceae (E. coli and Klebsiella), and confers resistance to every penicillin derivative. Like the KPC genes, this gene is found on miniature chromosomes that also carry other resistance genes, making this…

I’m conflicted about Nicholas Kristof’s recent op-ed about antibiotic resistant organisms. On the one hand, Kristof is one of the only national columnists to raise this issue at all. On the other hand, I found his most recent column somewhat confusing–and I’m an expert in this area (I also think he’s jumping to unfounded conclusions,…

(from here) By way of Maryn McKenna, we find that the Obama Administration has decided to massively cut the funding for the CDC’s antimicrobial resistance and vaccination efforts. I thought this was the kind of anti-science bullshit that the Bush Administration did. From the IDSA (pdf): Under CDC’s proposed budget, the agency’s already severely strapped…

Yesterday, four people emailed me, asking about Brian Palmer’s Slate article about antibiotic resistance. Since I’ll probably get more such emails (and thank you for sending them), I’ll offer my thoughts below: 1) Palmer’s basic point about antibiotic development not being the answer is right. All a new drug does is kick the can down…

I’ve been looking at the House and Senate Bills, and, on antibiotic resistance, they’re not bad. Both bills would evaluate hospitals on hospital-acquired infection rates (although there’s no mention of nursing homes, which are a significant focus of infection). This is good.

In the midst of the concern about TEH SWINEY FLOO!, very few people (other than the Mad Biologist), have been discussing the double whammy of influenza followed by bacterial infections. A couple of years ago, I first started describing reports of KPCs: No, KPC isn’t a new fast food restaurant. It’s short for Klebsiella pneumoniae…

A couple of weeks ago, after I posted about a very serious emerging bacterial threat, KPC, I received an email from a reader with an elderly relative in the hospital with a very serious case of pneumonia caused by KPC. What he* told me is shocking.

KPC: An Emerging Threat

No, KPC isn’t a new fast food restaurant. It’s short for Klebsiella pneumoniae carbapenemase. The bad news: it’s very hard to treat. The good news: it’s very rare…for now.