Desflurane (General Fluorine) : Molecule of the Day

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Desflurane (General Fluorine)

Category: Drugs
Posted on: January 16, 2007 9:00 AM, by Molecule of the Day

General anaesthesia has come so far, and yet not. Back in the day, we used to use lipophilic compounds like diethyl ether and alkyl halides like chloroform, and now we use...well, lipophilic alkyl halides like desflurane. Fortunately, desflurane doesn't cause so many toxic effects, due largely to the wonderful relative inertness of the C-F bond.

InChI=1/C3H2F6O/c4-1(3(7,8)9)10-2(5)6/h1-2H

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Comments

Dear MotD-editor,

thanx for your nice blog. What would I need to do to convince you to add some simple markup to allow Chemical blogspace [1] pick up the molecules you blog about daily? Would autogeneration of certain properties [2] be interesting as favor in return? Or maybe a widget with a list of other blogs/items that talk about this molecule?

I would very much appreciate your feedback, to hear how recent chemoinfo techniques can make chemical blogging even more interesting.

1.http://wiki.cubic.uni-koeln.de/cb/inchis.php
2.http://chemicalblogspace.blogspot.com/2007/01/redyellow-fda-alerts-and-other.html

Posted by: Egon Willighagen | January 16, 2007 10:56 AM

http://www.anesthesia-analgesia.org/cgi/content/full/88/5/1161
structure-function
Convulsions at ~0.005 atm partial pressure, including perfluorotoluene.

Fluorinated ethers were used to trigger convulsions to "cure" depressed and schizophrenic psychiatric patients. When shrinks got a whiff they got cured too. Insulin-induced hypoglycemic shock and pentamethylenetetrazole convulsions were icky. Electroshock won the day given its spiffy hardware, low cost, and ease of use - plus a side market for government re-education facilities.

Posted by: Uncle Al | January 16, 2007 11:48 AM

Egon-

My entries all have had inchi in the alt tag for a few months now. Is this not working for some reason?

Posted by: MoTD | January 16, 2007 12:36 PM

Not to mention it's not nearly as flammable as some of the old anesthetics were. I heard somewhere that in the earlier operating theatres they had to go to great lengths to reduce the possibility of static discharge and general sparkage to reduce the likelyhood of setting the anesthetic, patient, doctors, and hospital on fire.

Posted by: Jon | January 16, 2007 3:52 PM

Hi MoTD,

I just added support for of which you can see the result in Chemical blogspace.

Posted by: Egon Willighagen | January 17, 2007 3:25 AM