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The author is not a physician. The content on this website does not, and is not intended to constitute medical advice. It should not be relied upon when making medical decisions. It is not intended as a substitute for advice from your physician or other healthcare provider.

February 28, 2007

Chlorogenic acid (More puzzling polyphenols)

Category: Food

I'm almost cheating, since this one is so closely related to cynarin. Chlorogenic acid is yet another compound found in artichokes, as well as coffee. In addition to modulating your ability to taste sweetness (though not in the levels or...

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February 27, 2007

Cynarin (Artichokes and that sweet taste)

Category: Food

I am always completely confused when I meet someone who doesn't like artichokes. Not in the cheese-based dip, though that's not bad, either. I take my artichokes steamed, with a big bowl of drawn salted butter. The savory-sweet taste, the smooth texture, that puzzling satisfaction of only getting a little food out of your substantial efforts (sunflower seeds, anyone?), and the fact that it's probably the only food you eat by biting down and pulling the free end from your mouth all add to the experience.

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February 26, 2007

Isohumulone (Bitter Beer Face)

Category: Food

Great entry from Khymos last week. Isohumulone is a compound found in beer imparting some of the (good) bitterness. Unfortunately, the magic of photochemistry can wreak havoc on it....

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February 24, 2007

Havidol Redux

Category: Drugs

See also this followup. Take another look at the Havidol post's comments. It looks like the chemistry's not only a little bit off - some other parts of the site look a little familiar. And by the way, it's HCl,...

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February 23, 2007

Ammonium carbonate (Stinky leavening)

Category: Stinky

Ammonium carbonate is analogous to the other bicarbonate and carbonate salts you see - baking soda. In the presence of acid; or just sufficient heat, it will offgas ammonia and carbon dioxide, hopefully leaving pleasing bubbles in whatever you're making....

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February 22, 2007

Diethyl pyrocarbonate/DEPC (Making the world safe for RNA everywhere)

Category: Biology

It's remarkable how different RNA and DNA are, considering they're just one atom different. RNA is much more prone to fall apart; you can put DNA in basic solution without any problem, but RNA will begin to hydrolyze. Life takes...

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February 21, 2007

Denatonium/Bitrex (Mmm...less-toxic denatured alcohol)

Category: Hygeine

Denatonium, sold as Bitrex, is among the most bitter compounds in the world. Why in the world would industry seek out such a thing? To put in things we don't want you to eat, silly....

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February 20, 2007

Havidol (Hopefully the only fake molecule of the day I'll ever do)

Category: Drugs

See also the followups (one, two) to this post. From the taking jokes too seriously department... Havidol is a fake drug campaign by Justine Cooper that's on display in NY at the Daneyal Mahmood gallery (warning, slow loading, natively embedded...

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February 16, 2007

Cinnamaldehyde (Be aware: your cookie consumption is being watched)

Category: Food

Cinnamaldehyde is a straightforward-looking molecule: It's the principal odorant in cinnamon. If you're in the Seattle area, your cinnemaldehyde use is being monitored. Drug precursor? Guess again......

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February 15, 2007

Muscone (Sixty percent of the time, it works every time!)

Category: Perfumey

Synthesizing big cyclic molecules is hard ("macrocycles") - closing a long chain of carbons into a ring often results in just making polymers and oligomers ("intermolecular" reactions). One early way of closing rings on themselves ("intramolecular" reactions) was to perform the reaction at high dilution. An example is illustrative:

Take an empty swimming pool and fill it 10% of the way up with snakes. Observe how the snakes are much more likely to bump into each other than curl up on themselves. This is analogous to an intermolecular reaction.

Obtain a second swimming pool and fill it 90% of the way with water. Now dump the same number of snakes in. If necessary, you can reuse the snakes from part 1. Observe how the snakes are much less likely to bump into one another, and many will end up touching part of themselves with another part of their body. This is analogous to an intramolecular reaction. As go snakes, so go long chains of carbon.

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