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« Benzyne (Cyclic alkynes? Almost...) | Main | Methotrexate (Fakin' folate) »

Folic Acid (Not just for pregnant women)

Posted on: March 6, 2007 8:06 PM, by Molecule of the Day

Folate is a cofactor, or a small molecule that is involved in the function of an enzyme. It's involved in a number of enzymatic reactions; perhaps the most important relate to the biosynthesis of DNA.

# InChI=1/C19H19N7O6/c1-26(12-8-21-15-14(23-12)17(30)25-19(20)24-15)10-4-2-9(3-5-10)16(29)22-11(18(31)32)6-7-13(27)28/h2-5,8,11H,6-7H2,1H3,(H,22,29)(H,27,28)(H,31,32)(H3,20,21,24,25,30)/t11-/m0/s1

It's amazing to think about the fact that we've only known about its existence for seventy-odd years, considering its crucial role in metabolism. No doubt this was (partly) due to the fact that the requirement for folate is vanishingly small; it's on the order of half a milligram a day! Because of folate's central role in DNA synthesis (along with various other reactions, many of which are crucial to cell division); folate deficiency in pregnant women can be potentially dangerous. Any "prenatal vitamin" will contain folate because of this.

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