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« Proflavine (More DNA Dyes) | Main | Eszopiclone/Lunesta (Not quite Valium) »

Seroquel/Quetiapine (Give me a calmative!)

Posted on: March 13, 2007 8:14 PM, by Molecule of the Day

Seroquel antagonizes serotonin, dopamine, and histamine, but it doesn't look a whole lot like any of these:

InChI=1/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2

The benzothiazepene (benzene fused to the seven-membered ring containing nitrogen and sulfur) ring system bears a little resemblance to the benzodiazepines, the class to which Valium belongs, but sulfur and nitrogen are completely different kettles of fish from almost every standpoint - not to mention the rest of the ligand, particularly the piperazine (six-membered ring containing two nitrogens) moiety.

Seroquel finds use as an antipsychotic, along with numerous off-label uses.

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Little pink pills...to be taken in the evening...

Posted by: coturnix | March 13, 2007 11:20 PM

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