Molecules: You'd better learn to live with them.
From medicated powder to cigarettes, it's no secret that small molecule ligands can induce a cold sensation. Usually, this means menthol. However, like any protein ligand, non-natural small molecules can stand in.
Icilin has an enhanced affinity for receptors to which menthol binds:
Icilin induces sensations of intense cold when applied orally in humans, and induces 'wet dog shakes', a behavioral marker of cold sensation, when given to rats.
Icilin: 2.5X more effective than the leading thermosensory agonist at causing wet dog shakes!
Comments
Where do you find all these amazing molecules?
I've been following this blog for some months now, and although not a chemist I find it fascinating the array of molecules humans have synthesized for any conceivable purpose.
Posted by: jett | May 26, 2007 5:24 PM
How does Icilin compare to Menthol as far as Toxicity? I know menthol is relativly safe, but what about icilin?
Posted by: joeylawn | May 29, 2007 1:27 AM
http://www.nature.com/news/2007/070528/full/070528-5.html
Posted by: Uncle Al | May 30, 2007 4:29 PM