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The author is not a physician. The content on this website does not, and is not intended to constitute medical advice. It should not be relied upon when making medical decisions. It is not intended as a substitute for advice from your physician or other healthcare provider.

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Polyphosphoric Acid (Burning honey)

Category: Synthesis
Posted on: June 13, 2007 8:47 PM, by Molecule of the Day

Polyphosphoric acid is a mixture of phosphoric acids and its anhydrides:

InChI=1/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)

I like it as an acid catalyst in organic synthesis - a lot of people hate it because it's so thick and hard to handle. The stuff is absolutely gooey mess; when you heat it up, it gets down to about the consistency of honey. The neat thing is that lots of stuff will go into it (it is a strong acid goo, after all), but once you quench your reaction with water, your stuff will often crash out.


During a blissful few months, I cranked out a series of Fischer indoles with the stuff. Everything seemed to work!

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