Uracil mustard is a mimic of the RNA component and DNA precursor uracil, and it also has a few reactive ends that can do some damage.
Those chlorines amount to very reactive ends; the idea here is that they're hopefully a little better targeted than generally toxic molecules like the plain old nitrogen mustards. Hopefully, most of your cancer drug ends up in cancer cells, and targeting DNA bases (which they go through like crazy) has been a common strategy.
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