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« Valproate (Do we know anything about drug design?) | Main | Lead (II) Chromate (It's like a toxic party!) »

Triethylene Tetramine (Surprise, a polycation binds DNA)

Category: Drugs
Posted on: January 15, 2008 10:59 PM, by Molecule of the Day

A few months ago, a group published a report that this polyamine was an effective quadruplex ligand, inducing senescence of cancer cells.


It's perhaps unsurprising that this works. I've previously covered Telomestatin (more selective) and TMPyP4 (less selective), but man, just a big charged chain of stuff? Apparently, though, this molecule is used in vivo already, in chelating copper ions in the treatment of Wilson's disease.

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1

fyi, the title and caption are different. I think the title should be 'triethylene ...'

Posted by: azmanam | January 16, 2008 7:35 AM

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