Molecule of the Day

Stick that TBDMS on Monday and helplessly flailing around, looking for a way to get your alcohol back? Have a little TBAF:


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TBAF is one of the most common sources of fluoride ion for silyl deprotection. You usually get a 1M solution in THF with a little water, too. It can be a pain to get rid of when you’re not working with big, greasy, drug-like molecules and you’re working with water-soluble molecules like RNA.