Silibinin (Liver? I hardly knew her!)
As Uncle Al mentioned, many antioxidants are ill-tolerated by the liver. However, it loves one antioxidant: silibinin....Posted on April 3, 2008 9:00 AM • 2 Comments • 0 TrackBacks
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Molecules: You'd better learn to live with them.
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- More on Volatile Buffers
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The author is not a physician. The content on this website does not, and is not intended to constitute medical advice. It should not be relied upon when making medical decisions. It is not intended as a substitute for advice from your physician or other healthcare provider.
Drugs:
Doxorubicin (Red devil)
As I mentioned in the previous entries on HF, mercury fulminate, and phosphine, I really like Breaking Bad. As an astute commenter noted yesterday, they sometimes make some mistakes:...Posted on March 7, 2008 9:00 AM • 2 Comments • 0 TrackBacks
Dutasteride/Avodart (How does he crumple clay like that?!)
Dutasteride is of the same class of drug as Propecia and Proscar - the so-called 5-alpha-reductase inhbitors. These inhibit the enzyme of this name from converting testosterone into dihydrotestosterone....Posted on February 27, 2008 9:51 PM • 3 Comments • 0 TrackBacks
Psoralen (This molecule kills fascists)
Certain derivatives of coumarin called psoralens have the effect of sensitizing you to the sun. This can be useful for treating certain skin conditions with psoralen plus a little UV lights. It can also get you really, really tan. The...Posted on February 8, 2008 7:49 PM • 4 Comments • 0 TrackBacks
Quarfloxin (Quadruplexes in the clinic)
As I've mentioned before, I'm a booster for DNA G-quadruplexes as drug targets. While telomeres might not be the best target, there are lots of potentially oncogenically relevant quadruplexes. Here is the only quadruplex-targeting antineoplastic that's made it into the...Posted on February 5, 2008 9:41 PM • 0 Comments • 0 TrackBacks
Triethylene Tetramine (Surprise, a polycation binds DNA)
A few months ago, a group published a report that this polyamine was an effective quadruplex ligand, inducing senescence of cancer cells....Posted on January 15, 2008 10:59 PM • 1 Comments • 0 TrackBacks
Valproate (Do we know anything about drug design?)
I love the story of valproate. About fifty years ago, an investigator was using a fatty carboxylic acid as a delivery vehicle for antiseizure medications. He looked at it alone in controls and, lo and behold, it was a drug...Posted on January 14, 2008 9:19 PM • 4 Comments • 0 TrackBacks
Propofol (Milk of Amnesia)
Anaesthetics are weird. Much of what we use has a paucity of the oxygens and nitrogens that seems to make most drugs work, and there's been substantial puzzlement and handwringing over exactly how some of these things work. Xenon, for...Posted on December 4, 2007 9:11 PM • 3 Comments • 0 TrackBacks
Varenicline/Chantix (Not like the others)
Smoking cessation is tricky business - most of the time, people have used nicotine replacement therapy (the patch, the gum, etc) or CNS active drugs (like Wellbutrin/Zyban/Bupropion). None of it works that well - the manufacturers of today's molecule, Chantix,...Posted on November 19, 2007 9:11 PM • 4 Comments • 0 TrackBacks
Uracil Mustard (Not as tasty as regular mustard)
Uracil mustard is a mimic of the RNA component and DNA precursor uracil, and it also has a few reactive ends that can do some damage....Posted on October 10, 2007 9:00 AM • 1 Comments • 0 TrackBacks
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