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Antidepressants' side effects can run the gamut from inhibition of libido, to erectile dysfunction, to a diminished or complete inability to achieve orgasm. It's that last one that we take a look at today - a SSRI went on sale in Britain this week that is touted as inhibiting orgasm - on purpose!
I just read the excellent Not Rocket Science for the first time. He has a nice writeup of the propranolol story that is making the rounds. Some researchers conditioned some subjects to get stressed when they saw a picture of...
Levamisole is one of those drugs that was discovered quite awhile ago, when we had even less idea what target things were hitting. It's not used often in people these days. What's interesting about it is that it is occasionally...
Loratadine is an antihistamine used for treatment of allergies. Its main distinguishing characteristic is that it is nonsedating, because the molecule minimally penetrates the barrier separating the brain from the bloodstream....
As I mentioned yesterday, derivatives of arylethylamines - phenethylamine in particular - are drug targets in depression, but a sophisticated mechanistic understanding remains elusive. When you have some idea what molecule you'd like less of, a favorite trick is to...
An aromatic ring, two carbons, and a nitrogen will get you a lot of places.From hallucinogens to decongestants to speed, the arylethylamine moiety works because it tickles neurotransmitter receptors. The effects of the assorted monoamine neurotransmitters are as varied as...