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Molecules: You'd better learn to live with them.
Category: Drugs
Antidepressants' side effects can run the gamut from inhibition of libido, to erectile dysfunction, to a diminished or complete inability to achieve orgasm. It's that last one that we take a look at today - a SSRI went on sale in Britain this week that is touted as inhibiting orgasm - on purpose!
Posted by Molecule of the Day at 9:00 AM • 8 Comments • 0 TrackBacks
Category: Drugs
Wow. It's not just anticancer drugs for dogs, there are also "lifestyle" drugs. They think they're people!...
Posted by Molecule of the Day at 9:00 AM • 4 Comments • 0 TrackBacks
Category: Drugs
A few months ago, a tyrosine kinase inhibitor anticancer drug for people, this month, one for dogs....
Posted by Molecule of the Day at 8:29 PM • 5 Comments • 0 TrackBacks
Category: Drugs
I just read the excellent Not Rocket Science for the first time. He has a nice writeup of the propranolol story that is making the rounds. Some researchers conditioned some subjects to get stressed when they saw a picture of...
Posted by Molecule of the Day at 8:30 PM • 6 Comments • 0 TrackBacks
Category: Drugs
Levamisole is one of those drugs that was discovered quite awhile ago, when we had even less idea what target things were hitting. It's not used often in people these days. What's interesting about it is that it is occasionally...
Posted by Molecule of the Day at 9:40 PM • 11 Comments • 0 TrackBacks
Category: Drugs
Loratadine is an antihistamine used for treatment of allergies. Its main distinguishing characteristic is that it is nonsedating, because the molecule minimally penetrates the barrier separating the brain from the bloodstream....
Posted by Molecule of the Day at 7:53 PM • 1 Comments • 0 TrackBacks
Category: Drugs
Cyprodenate is an old antidote for benzodiazepene overdose:...
Posted by Molecule of the Day at 7:27 PM • 5 Comments • 0 TrackBacks
Category: Drugs
As I mentioned yesterday, derivatives of arylethylamines - phenethylamine in particular - are drug targets in depression, but a sophisticated mechanistic understanding remains elusive. When you have some idea what molecule you'd like less of, a favorite trick is to...
Posted by Molecule of the Day at 7:51 AM • 7 Comments • 0 TrackBacks
Category: Drugs
An aromatic ring, two carbons, and a nitrogen will get you a lot of places.From hallucinogens to decongestants to speed, the arylethylamine moiety works because it tickles neurotransmitter receptors. The effects of the assorted monoamine neurotransmitters are as varied as...
Posted by Molecule of the Day at 1:14 AM • 2 Comments • 0 TrackBacks
Category: Drugs
As Uncle Al mentioned, many antioxidants are ill-tolerated by the liver. However, it loves one antioxidant: silibinin....
Posted by Molecule of the Day at 9:00 AM • 2 Comments • 0 TrackBacks
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