Now on ScienceBlogs: The Australian's War on Science 41
Molecules: You'd better learn to live with them.
Category: Synthesis
Stick that TBDMS on Monday and helplessly flailing around, looking for a way to get your alcohol back? Have a little TBAF:...
Posted by Molecule of the Day at 11:14 PM • 0 Comments • 0 TrackBacks
Category: Synthesis
Just like boc protects amines, TBDMS protects alcohols....
Posted by Molecule of the Day at 9:17 PM • 5 Comments • 0 TrackBacks
Category: Synthesis
Sodium borohydride is intermediate to the jackhammer that is LAH and the pussycat that is cyanoborohydride....
Posted by Molecule of the Day at 9:40 PM • 3 Comments • 0 TrackBacks
Category: Synthesis
A lot of reactions with nucleophiles' rates are determined by how good a leaving group you have. For leaving group reasons and others, DMAP is a great organocatalyst:...
Posted by Molecule of the Day at 12:22 AM • 0 Comments • 0 TrackBacks
Category: Synthesis
That was probably the longest break ever. I'm trying to do better, but writing up multiple papers and grant applications, along with a pretty intense summer travel schedule just haven't augured well for the blogging. Onward and upward: tetrazole....
Posted by Molecule of the Day at 10:39 PM • 3 Comments • 0 TrackBacks
Category: Synthesis
Automated solid-phase synthesis of biomolecules defines 20th century biology. I previously covered a protecting group that is ubiquitous in DNA synthesis, but the Nobel was actually awarded for peptide chemistry....
Posted by Molecule of the Day at 10:30 PM • 1 Comments • 0 TrackBacks
Category: Synthesis
Chlorinated solvents are great solvents. The polarizability of chlorine, moderate electronegativity, moderate volatility, lack of acidic protons or reactivity - it all adds up to a great reaction medium. However, they usually are toxic....
Posted by Molecule of the Day at 8:49 PM • 7 Comments • 0 TrackBacks
Category: Synthesis
Everyone knows that many organic solvents won't mix with water (or, more generally, some polar solvents won't mix with some nonpolar solvents). What you might not know is that some highly fluorinated liquids aren't very polar at all, but they...
Posted by Molecule of the Day at 10:48 PM • 7 Comments • 0 TrackBacks
Category: Synthesis
So people gush over bmim and get the guaranteed publications for including "ionic liquid" in the title of their article. Ionic liquids are far from the newest fad, though, they've been around for nearly 100 years!...
Posted by Molecule of the Day at 9:13 PM • 2 Comments • 0 TrackBacks
Category: Synthesis
When you take organic chemistry, you learn about methyl iodide for putting on a methyl group. Eventually, though, if you stick with chemistry, you need an alkylating agent for grown-ups....
Posted by Molecule of the Day at 11:32 PM • 5 Comments • 0 TrackBacks
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Starts With a Bang 11.04.2009
