Developmental Biology

Neurophilosophy

Category archives for Developmental Biology

The turning point

[Introduction|Part 2|Discussion] Tojima et al (2007) find that the growth cone’s response to attractive guidance cues requires asymmetrical vesicle transport and exocytosis. They cultured dorsal root ganglion (DRG) cells from embryonic chicks, and produced localized elevations in calcium ion concentration on one side of the growth cone by photolytic release of the caged calcium ion…

A novel axon guidance mechanism

[Introduction|Part 3|Part 4] Lopez-Bendito et al (2006) show that pathfinding of thalamocortical axons (TCAs) requires the formation of a permissive corridor through non-permissive territory, and that this corridor is generated by cells which undergo a tangential migration from the lateral ganglionic eminence (LGE). TCAs arise in the dorsal thalamus, and follow a stereotyped pathway into…

The growth cone

Dylan T. Burnette/ Nikon Small World.  The remarkable specificity of neuronal connectivity depends on accurate axon pathfinding during development. Pathfinding involves the detection of guidance cues in the environment by the growth cone, a motile chemotactic structure at the leading tip of the extending axon. The growth cone was discovered over 100 years ago by…

Journal club

Below is the PowerPoint I presented in the journal club this morning. It’s a summary of a recent paper about laterality in the nematode worm: Poole, R. J. & Hobert, O. (2006). Early embryonic programming of neuronal left/right asymmetry in C. elegans. Curr. Biol. 16: 2279-2292. [PDF] I mentioned this study in yesterday’s post about…