CNS Diseases and Disorders

Neurotopia

Category archives for CNS Diseases and Disorders

Best. Modelling Paper. Ever.

The abstract says it all: Zombies are a popular figure in pop culture/entertainment and they are usually portrayed as being brought about through an outbreak or epidemic. Consequently, we model a zombie attack, using biological assumptions based on popular zombie movies. We introduce a basic model for zombie infection, determine equilibria and their stability, and…

I wanted to draw attention to a new paper in JAMA recently because it reveals a lot about how conditional most of the statements we make in behavioral genetics are. Every time you hear a news article that says, “Gene for depression found,” I want you to think about this case. Risch et al. performed…

Some people have been noticing erratic behavior from republican nominee John McCain lately. His most recent seems to be slight, but rather odd. Specifically, he appears to have developed ptosis— a drooping eyelid— which could of course be related to any number of causes, from an autoimmune attack on cholinergic receptors such as that seen…

Memantine is the most recent weapon in the fight against Alzheimer’s. There’s been a lot of hype surrounding the drug because…. The first-generation of compounds aimed to boost the brain’s acetylcholine levels led to the development of drugs such as Aricept™ (donepezil) and Excelon™ (rivastigmine). Attempts to develop drugs that block the action of glutamate…

Abel over at Terra Sigillata got is writ in a tinger over bad grammar and was concerned that Alzheimer’s Disease had been tied to risky sexual behavior. His conclusion was that he got a poorly worded email notice about two separate problems that were linked inappropriately by a semicolon. So everything’s fine, all clear, right?…

Depression is all in your head….

…but for those who suffer from it, “in your head” can be more debilitating than other chronic, painful illnesses. A massive WHO survey study of 60 countries reported that 3.2% of people had depression over the course of a year. Interestingly, though… This was a bit lower than for asthma (3.3 percent), arthritis (4.1 percent),…

Finally we get some data on changes in AD pathology with statin use! Statins are taken for lowering cholesterol, but they have other beneficial effects such as modulating inflammatory responses. Thus, they could prove beneficial in the treatment of AD given the disease has a significant inflammatory component. According to the press release The two…

Yes, that title is a bit ostentatious. But the foods we eat contain many compounds that can be beneficial to brain health. One strategy for optimizing our brains for long-term peak performance is to identify these compounds and discover how they are beneficial. Head-healthy chemicals have previously been isolated from curries and spices before, and…

This is the third part in an overview of menopause and hormone therapy. Parts one and two are

Temporal lobe epilepsy (TLE) refers to a condition where recurrent seizures arise in the temporal lobe of the brain. This condition is seen in humans and animals. Often, TLE arises following a neural insult such as head trauma or tumor, but can also be triggered by infection. These febrile seizures are often seen in children…