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Neurotopia (version 2.0)

Stronger. Faster. Bloggier. Now chock full of glial goodness. **Warning** contains one giant neuro-nut.

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EVIL.jpg The Evil Monkey has a Ph.D. in Neuroscience and is currently enjoying a bit of time off while waiting to hear about a new position. Come join this wayward neuroscientist as he struggles to find a career and get his life back in order. He is still not sure why he wrote this paragraph in the third person.

Disclaimer: The opinions on this blog do not represent any organization to which I may belong, or employers, or basically anybody but myself. So there.

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CNS Diseases and Disorders:

Oops! Memantine's actions really aren't all that and a bag of chips

Memantine is the most recent weapon in the fight against Alzheimer's. There's been a lot of hype surrounding the drug because.... The first-generation of compounds aimed to boost the brain's acetylcholine levels led to the development of drugs such as...

Alzheimer's Disease and risky sexual behavior: not quite a false alarm?

Abel got a badly worded email which made him worried that Alzheimer's may be caused by sexually transmitted diseases. Turns out he's not completely off the mark.

Depression is all in your head....

...but for those who suffer from it, "in your head" can be more debilitating than other chronic, painful illnesses. A massive WHO survey study of 60 countries reported that 3.2% of people had depression over the course of a year....

Promising Effects of Statins on Alzheimer's Pathology

Finally we get some data on changes in AD pathology with statin use! Statins are taken for lowering cholesterol, but they have other beneficial effects such as modulating inflammatory responses. Thus, they could prove beneficial in the treatment of AD...

Eat chana masala to prevent Alzheimer's!

Yes, that title is a bit ostentatious. But the foods we eat contain many compounds that can be beneficial to brain health. One strategy for optimizing our brains for long-term peak performance is to identify these compounds and discover how...

The Basics of Menopause and Hormone Therapy III: Cognitive Consequences

Postmenopausal women frequently complain about problems with attention and concentration, and increased forgetfulness. Controlled studies of the cognitive effects of menopause and HRT, however, have been controversial.

Status Epilepticus, TLE, and GABA-A Receptor Gene Therapy

Temporal lobe epilepsy (TLE) refers to a condition where recurrent seizures arise in the temporal lobe of the brain. This condition is seen in humans and animals. Often, TLE arises following a neural insult such as head trauma or tumor,...

The Importance of Biodiversity, or Yet Another Interesting Toxin

Looks like yet another interesting toxin was found, this time in a venomous snail. This discovery comes from the lab of an old player in the field, who apparently discovered the conotoxin that is used in Prialt....

Antisense Oligonucleotide Therapy for ALS patients?

Amyotrophic Lateral Sclerosis is a devastating disease that claims the upper and lower motor neurons, and ultimately the lives of most patients within 3-5 years of diagnosis, usually from respiratory failure. Patients lose control of voluntary muscles as the pathways...

Everybody Post About Mirror Neurons!!!

Mixing Memory brings up some excellent points regarding mirror neurons in primates, and Frontal Cortex follows up with his thoughts. To both of them I say "bravo, but your skepticism probably doesn't go far enough". We give Rizzolatti et al...

Stem Cells for Spinal Cord Injuries

The difficulty with treating spinal cord injuries arises from a number of factors. Firstly there is the primary damage to the axons of the spinal cord itself, resulting in mechanical damage that can inhibit neurotransmission and transport of cellular material...

Pesticide-induced dysfunction of dopaminergic neurons

Shelley mentioned a study last week that suggested more and more young people are getting Parkinson's Disease, and she wondered whether there was any utility in blaming our industrialized society based on the fact that certain compounds we produce can...

SIRT1 Pathways and the Prevention of Alzheimer's Pathology

A highly conserved set of genes known as the sirtuin family are known to be activated by caloric restriction (CR) and extend the lifespan of a number of species. CR may also reduce the risk of Alzheimer's Disease, and can...

And when you're in your bigger room...

...you might not know what to do you might have to think of how you got started sittin' in your little room --The White Stripes...

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