Not Exactly Rocket Science


Blogging on Peer-Reviewed Research
People in most parts of the world are living longer and longer, thanks to great leaps in medicine and sanitation over the last century. But these growing life expectancies bring with them a sense of unease. The biggest worry is the possibility that medical advances are artificially prolonging life with little regard for its quality. Old age, after all, brings with it an increased risk of chronic diseases such as cancer, as well as both physical and mental decline.

i-061273b479fa954337a3c4d7a98b8231-Old-man.jpg This is not just a moral question, but an economic one too. The “oldest-old” are the fastest growing demographic in Western countries. If this expanding part of the population is indeed becoming more and more dependent on care from relatives or the state, the costs to society will start to skyrocket. But new research from Denmark suggests that this grim vision of the future is a fictitious one.

Kaare Christensen and colleagues from the University of Southern Denmark found that the proportion of elderly Danes who manage to remain independent holds steady at about 30-35 percent between the ages of 90 to 100. Individual people certainly risk losing their independence as they get older but the unhealthiest ones tend to pass away earlier despite improvements in medicine. This means that from society’s point of view, exceptional long-life won’t lead to exceptional levels of disability.

The scale of Christensen’s study is unprecedented. It exploited the fact that Denmark has kept a record of everyone living in it since 1968. Each person is assigned with a 10-digit identification number that links all their information across official registries. In 1998, Christensen’s team used this resource to contact every one of the 3,600 people who were born in Denmark in 1905 and were still alive.

About two-thirds of this group of ninety-somethings agreed to take part in the research. Christensen assessed their physical strength, their ability to get on with daily life, their mental agility and whether they showed any symptoms of depression. His team then caught up with them again in 2000, 2003 and 2005. At every stage, there were a few drop-outs due mostly to deaths and terminal illness and by 2005, only 166 volunteers remained, all of whom were 100-years old. 

These drop-outs tend to pose problems for studies like these that follow groups of people over time. But in this case, it gave the researchers a chance to compare the health of those who stayed with the study and those who didn’t. As you might expect, they found that the drop-outs tended to have weaker physical and mental abilities and were more likely to show signs of depression than those who stuck with it.

At each of the four assessment years, the team found that the proportion of survivors who remained physically and mentally independent stayed remarkably stable. Even among the centenarians interviewed in 2005, a third were self-sufficient.

Society vs. individual

i-0ecbecf2812196f8e61a3d4a5953703a-Ageing.jpgDoes this mean that people don’t become frailer as they age? Hardly. Remember that we’re looking at the trends at a population level. At an individual level, the more expected trend of failing health is more obvious – for example, 70% of the people who would eventually live to 100 were independent at the age of 93 and this proportion fell to 32% over the course of seven years. The thing that separated the super-elderly from the elderly was that their decline of body and mind started later.

To picture this more clearly, imagine a group of a 90 friends all of whom are at a ripe old age. About 30 of them (a third) are fully independent and enjoying the rudest of health, while another 30 or so are severely disabled and very ill. Skip forward a decade or so and this very disabled fraction have passed away, leaving behind 60 of their friends. But the health of some of these survivors has also taken a turn for the worse; now only 20 people (out of the 60) are fully independent and another 20 have taken seriously ill. Note that while overall, the health of the group is failing, the proportion of independent people is still the same – a third!

So as the population ages, the most disabled people are likely to die off sooner, leaving behind a steady proportion of good health.  That’s good news for Western societies because it suggests that extending lives isn’t going to wreak an overly exorbitant cost in terms of healthcare. Even with lives reaching beyond the 90-year mark, it’s hardly the case that entire sections of society will be bedridden. Indeed, a recent study of 32 Americans aged 110 and over found that 40% of these “supercentenarians” could look after themselves.

Christensen’s conclusions are backed up by another study by James Lubitz published in 2003. Lubitz looked at the relative healthcare costs of looking after people aged 70 for the rest of their lives. His team found that healthy 70-year-olds exacted less of a cumulative healthcare cost than those with partial disabilities, even though they lived for a longer time.

Christensen says that his research might seem like good news for society and bad news for the individual, but that there’s reason to be optimistic. The study shows that people who survive to the highest ages have “a health profile that is similar in many aspects to most individuals who are 7 to 8 years younger”. He also notes that while his study looked at people who were born in 1905, other research suggests that disability could be kicking in even later for people born in subsequent decades years.

In both Denmark and the US, overall disability rates have been falling since the 1980s. What happens in the future is anyone’s guess – certainly, the fact that fewer and fewer people are smoking can only push back the onset of disability in old age, but the obesity epidemic may pull the trend back in the opposite direction.

Update: Jonah Lehrer at the Frontal Cortex deserves your time with a great piece on the recent spate of “age defiance” (think Madonna), with a nice lashing of neuroscience.

Reference: PNAS doi:10.1073/pnas.0804931105

Images: Old man by Rubens; graph from PNAS

Comments

  1. #1 HolfordWatch
    August 18, 2008

    It is so difficult to get a good feel for this. iirc there was a lot of interest last year when it seemed that older people were reporting a remarkable amount of disability at the same time as other indices were indicating that older people had never been so healthy and robust.

    There was an intriguing article in the NYT in 2006 about studies by Robert Fogel and various other researchers: So Big and Healthy Grandpa Wouldn’t Even Know You.

    The biggest surprise emerging from the new studies is that many chronic ailments like heart disease, lung disease and arthritis are occurring an average of 10 to 25 years later than they used to. There is also less disability among older people today, according to a federal study that directly measures it. And that is not just because medical treatments like cataract surgery keep people functioning. Human bodies are simply not breaking down the way they did before.
    Even the human mind seems improved. The average I.Q. has been increasing for decades, and at least one study found that a person’s chances of having dementia in old age appeared to have fallen in recent years.
    The proposed reasons are as unexpected as the changes themselves. Improved medical care is only part of the explanation; studies suggest that the effects seem to have been set in motion by events early in life, even in the womb, that show up in middle and old age.

    There was a high degree of disability and chronic illness at what we might consider to be comparatively young ages. If forecasts and studies like the one that you report are correct, we are likely to be older before we do that and perhaps more of us might make it to a ripe old age with a lesser degree of disability or illness.

  2. #2 Mike
    August 19, 2008

    Ed, great article.

    If you’re interested in some of the sociological implications of extreme lifespans you should try to get your hands on an article entitled, “The Coming Death Shortage”, by Charles C. Mann. It was published in The Atlantic Monthly in 2005. It can be found in The Best American Science Writing: 2006.

    It gives a great discussion as to what happens when people live to upwards of 130, how this will create conflicts with younger generations, and looks at the beginning of this demographic shift already taking place, most notably Japan.

  3. #3 Kevin
    August 19, 2008

    This article is why I read this blog. An accessible digest of research results with links to other resources.
    Good job!

  4. #4 Ed Yong
    August 19, 2008

    Thanks for comments and suggestions guys. I’ll definitely follow up on those articles. Might make a good feature.

  5. #5 Amiya Sarkar
    August 20, 2008

    Encouraging and eye opening. With physique and psyche in shape, we expect to live better when we grow old. But what about the elderly living in the developing countries?

  6. #6 Tony Sidaway
    August 23, 2008

    This reminded me of a book I’m currently reading, What Evolution is by Ernst Mayr. After a long career in biology, including a decades-long association with the American Museum of Natural History followed by 22 years on the Faculty of Harvard, he retired in 1975. After then, 14 of his 25 books were published as Professor Emeritus, as were some 200 articles in various journals. He continued writing until the end of his life. The book I am reading was completed whilst Mayr was in his 97th year, and he finally died in 2005 at the age of 100.

  7. #7 Eugeniy
    July 15, 2009

    Regardless if this research true or not, we better be young at all. We can change our DNA in such a way, cause there are animals with negligible senescence. It’s all about engineering. When we do that, everyone will decide for himself if (s)he use it or not.

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