Now on ScienceBlogs: That Which I Sowed in Tears, I Now Reap in Joy: A Love Letter to my Beautiful Readers

Seed Media Group

Omni Brain

An exploration of the serious/fun/ridiculous - past/present/future of the brain and the science that loves it.

The Homunculus

steve_icon_medium.jpgThe Omnibrain is a psychology graduate student at an online university. He hopes that the three weeks and $29.95 that he is spending on his Ph.D. will get him a job at a Tier 1 research university. Do online universities have postdocs? Ok...just kidding, The Omnibrain is a real graduate student at a real school somewhere in the continental United States - or maybe Europe.

Search

Recent Posts

Recent Comments

Archives

Blogroll

Bloggers' Rights at EFF

Channel N

Openlab 2007

Glial Cells

Access Omni Brain mobile here.

Access Omni Brain email here.

Axons

« Ok seriously - make up your mind about migraines! | Main | Does your name dictate who you are? »

Dandruff shampoo to calm seizures

Category: Neuroscience
Posted on: April 30, 2007 11:23 AM, by The Omnibrain

dandruff.jpgClearly, washing your hair isn't going to have any effect since I highly doubt that your Head and Shoulders is going to sink through your scalp, through bone, through your meninges and then go straight to the source of your seizures. But hey! If you can get your local neurosurgeon to open up your scalp, do some intracranial recordings to find the source of your seizures and then massage the shampoo onto your neurons you might have some luck. Don't forget to wash, rinse and repeat!

You should probably condition those newly cleaned cells while you're in there as well.

Here's the details
:

Epilepsy and other seizure disorders result when nerves excessively or inappropriately "fire" in the brain. The brain's "off" switches fail in part due to protein defects that prevent potassium from exiting nerve cells and calming them. "Channels that carry potassium," says Min Li, Ph.D., professor of neuroscience at Johns Hopkins, "must open on cue to make sure nerve cells only fire for defined periods of time."

In their studies of these channels, Li and his colleagues developed a new way of testing thousands of druglike molecules to find any that could turn the potassium switch on or off. Their approach involved chemically shaving off all the potassium channels on the cell surface and forcing the cells to make new channels. By measuring the activity of the new channels, the researchers could identify molecules that accelerated the recovery.

One chemical that proved quite effective in improving channel recovery was zinc pyrithione (ZnPy), the active ingredient in many dandruff shampoos. Li explains that ZnPy has a shape that allows it to fit into the gate region of the channel protein and allow more potassium flow. "If you think of these channels as doors on the cell's surface," Li says, "then ZnPy made this door both easier to open and stay open longer. It's like a tunable hinge that helps sticky doors swing freely."

The researchers then tested defective channels that contain the same mutations known in humans to cause mild epilepsy-like seizures in infants. Bathing cells with small amounts of ZnPy caused the mutant potassium channels to let three times as much potassium flow through, raising the possibility of restoring normal nerve cell activity.

Share this: Stumbleupon Reddit Email + More

TrackBacks

TrackBack URL for this entry: http://scienceblogs.com/mt/pings/39418

Post a Comment

(Email is required for authentication purposes only. On some blogs, comments are moderated for spam, so your comment may not appear immediately.)





ScienceBlogs

Search ScienceBlogs:

Go to:

Advertisement
Follow ScienceBlogs on Twitter
Visit the Collective Imagination blog
Advertisement

© 2006-2009 Seed Media Group LLC. ScienceBlogs is a registered trademark of Seed Media Group. All rights reserved.

Sites by Seed Media Group: Seed Media Group | ScienceBlogs | SEEDMAGAZINE.COM