…and this is a 
Student Post: The BrainGate Neural Interface System
Category: Neurobiology
Posted on: October 4, 2007 7:13 PM, by Katie Glasrud
As I pondered what to post about on Pharyngula this week my thoughts immediately turned to football *wink* ...which got me thinking spinal cord injuries (and no... not in the context of malice toward Drew Brees), which got me thinking of last year's Distinguished Alumni speaker, physiatrist (and poet!) Jon Mukland '80.
Dr. Mukland presented his research on the development of the BrainGate Neural Interface System-- a program designed to interface victims of spinal cord injury with a computer. A silicon chip implanted in the motor cortex uses feedback from hundreds of probes to map electrical activity patterns associated with certain motor tasks. For example, if the patient is asked to imagine they are moving a computer screen cursor to the left, the implant records the pattern of electrical activity associated with that function. A computer is programed to interpret that activity and move the cursor left when it receives that input again. This is duplicated for other kinds of movement. The result is that a the patient is able to manipulate a computer cursor with his or her mind.
Dr. Mukland went on the describe the benefits of this system. The ability to manipulate a cursor independently, even in limited ways, opens up a host of quality of life opportunities for paralysis victims. Computer programs could be designed to allow patients to turn on appliances, use the internet, or communicate electronically. As the technology improves, the implications for improved quality of life increase dramatically.
I've never been so proud to be a UMMer :)
Comments
What's a "physiatrist?"
Posted by: AnthonyH | October 4, 2007 8:15 PM
physician specializing in physical medicine and rehabilitation
Posted by: Katie | October 4, 2007 8:18 PM
definition of physiatrist:
http://www.aapmr.org/condtreat/what.htm
Posted by: cyan | October 4, 2007 8:19 PM
For a decade and more, I've been wondering why seeming breakthroughs in treatment of spinal chord injuries stubbornly refuse to translate into real-life benefits. It's been donkeys years since experimental mice could get much enervation back through freezing, precision slicing, and then approximation of a severed spinal chord. It's been a decade and more since a paraplegic college student was taught to walk by a computer, and it seems as though every 18 months or so someone with a spinal-chord defect or injury gets hooked up to a PC and moves the cursor.
But the folks whose spinal chords are injured tomorrow in auto accidents? They'll be para- or quadraplegics (or dead) just as they would have been a generation ago.
Maybe I've just been reading "framed" science all these years. (and I don't mean stryker!)
Posted by: PoxyHowzes | October 4, 2007 9:18 PM
Cursor moving is pretty cool, and certainly a big step for someone who can't otherwise move anything, but when do humans get the chips that can move robot arms? C'mon! Monkeys got robot arms! Why can't WE have robot arms? (With flamethrowers! And buzz saws! And...)
[Aside: I hope that PZ has said something to his students about ignoring the hell out of us here in comments]
Posted by: cerebrocrat | October 4, 2007 9:41 PM
That is simply incorrect. There are a considerable number of people now implanted with muscle implants that allow them to move their arms, hold things, stand up, even walk to an extent. You recall a few years ago that paraplegic walking down the isle for her wedding? What you probably didn't know is that systems like that have been implanted into a large number of people. That was pretty difficult for her to do, but using that implant to just stand up to reach things, move between chairs, get in and out of bed, and other such basic activities can considerably improve the quality of life for a paraplegic. Similarly, just being able to hold and drink from a cup, to grasp a fork or pencil, or other basic tasks, even if somewhat awkward, can also significantly help quadraplegics. These are not universal, but they are far more common than you probably realize.
As for hooking people up to computers, it may seem easy in theory but it is extremely difficult in practice. How much can the motor cortex rewire itself? What sort of signals should you look for and how should they be interpreted? The signals will likely change over time and depending on present conditions, how does the system handle that? How do you filter out all the other stuff happening in the brain? Do you have to put the electrodes in precisely the right spot or can it be anywhere? How many electrodes do you use? How deep should they be? How far apart should they be spaced? Should use one electrode per needle or several? What is the best shape for the electrodes? What should they be made out of? What sort of damage will it do, and what sort of damage is acceptable? Will the electrodes cause the brain to change over time so the system stops working? Will the electrodes stay in place under real-world conditions? Sending signal into the brain is easy, but how do you get a hundred or more channels of data out of the brain without breaking the skin (which will cause infection)? The brain can move around in the skull, how do your prevent the wires from fatiguing and breaking? It is easy enough to do the analysis when you have a large workstation computer and fancy A/D converter, but how do you do the A/D conversion, spike detection, and spike-train analysis calculation in a wearable unit? These are all issues that are easy enough to deal with in a lab but are much harder to deal with in a portable unit that can operate under real-world conditions and must last for decades if not a lifetime.
Posted by: TheBlackCat | October 4, 2007 9:48 PM
You don't even need implants. It can be done simply by wearing an EEG cap!
Posted by: DrBadger | October 4, 2007 10:30 PM
Interesting. Not having any good references available myself, can anybody tell me what the scale required here is? That is to say, what spacing between electrical sensors is required to recover nerve impulses adequately, and how many do you need?
Posted by: Brain Hertz | October 5, 2007 12:03 AM
Praise science!
This is the cool stuff we were promised when we were children (aren't I bit young to say that yet).
If I give my monkey army robotic arms, can they be hooked up through a wireless router so I can control them with my brain...
Your little dog stands no chance now!!
Posted by: zayzayem | October 5, 2007 12:12 AM
oops, link didn't work. here it is.
Posted by: DrBadger | October 5, 2007 12:13 AM
This is cool.
As a student of electrophysiology, I have to point out that an EEG could never allow for the spatial resolution that an implant does. And I'm fairly sure that you would need an implant to do communication too (signals both in and out of the brain).
To answer Brain Hertz's question - as good as you can get. But, from the looks of it we are nearing the limits of normal electrodes, as the closer the electrodes are (the higher the density of the chip), the more noise you pick up from neighboring electrodes.
It's a trick problem, and one I look forward to throwing myself at as soon as I can!
Posted by: Doddy | October 5, 2007 5:05 AM
Could we use nerves that are not "essential" to control devices? For example, take a nerve that goes to some organ that is not needed, like the appendix, put some electrodes in it, and connect those to an apparatus that responds to these signals and does somehting (like playing mp3s)?
I expect that doing that would require the patient to train himself to send the right signals to that nerve, but I do think that people can learn to do that.
Or is this not possible even in principle?
Posted by: Valhar2000 | October 5, 2007 6:02 AM
That's an interesting suggestion Valhar. Although your example wouldn't really be valid, because the signals from the appendix don't go to the auditory processing part of the brain.
Perhaps a better idea would be to grow new nerve pathways to hook up to the new device, or use an artificial nerve pathway to implant right into the correct area of the brain.
I wonder if the brain would be able to integrate the signals though. Certainly sound would be possible, but could one, for example, feel realistic tactile sensation from an artificial tail if it was connected to the somatosensory cortex?
Posted by: Doddy | October 5, 2007 6:53 AM
My apologies Valhar, I read your comment wrong.
You are proposing that the innervation to the appendix control an mp3 player, rather than an mp3 player send signals to the brain.
Well, the enteric nervous systemon (the nerves controlling the gut) are autonomic. That is, not under conscious control. Of course, while we're on the subject of brain modification, perhaps that could be changed too. But that brings me back to my above comment - how would the brain cope with novel stimuli or novel systems to control?
Posted by: Doddy | October 5, 2007 6:58 AM
Posted by: TheBlackCat | October 6, 2007 12:54 PM