Pharyngula

The argument from eyelid development

This is a new one for me. Earlier today I was summoned on Twitter to address an assertion by a creationist, @jarrydtrokis. I was slightly boggled.

He was baffled by eyelid development. It seems he thinks it requires…intelligent design!.

… Here’s one for you to ponder :) Eye lids in the womb… How are they formed? #IntelligentDesign?

Wait, what? What’s mystifying about eyelid formation?

The section of skin in the middle dies… How does it know to do that? And in a perfectly straight line???

Oh. It forms a straight line. Whoa. And he claims to have done research to get the answer.

The research I’ve done shows the scientists are at a loss for an explanation….

Gosh. I can do research, too. It’s easy to explain, with pictures even.

The eyelids separate in a straight seam because of how they got that way. The eyelids form by expansion of two epithelial sheets from above and below that meet in the middle. When you see how the eyelids develop, it’s easy to see how they separate in a straight line later. This is a series of images over the course of about a day in mouse development. In the first, you can see the eye sans eyelid, but ringed by epithelia. In the second, you can see that epithelium growing, expanding in a sheet over the eye. In the third, the sheet is beginning to close in a line over the middle, and in the fourth it has completely closed, but leaving a seam or scar in a straight line across it.

mouse_eyelid_sem

Wait, you say inquisitively, I’d like a closer look at that seam. Can you show me what is going on postnatally, as the eyelids separate? Sure can.

mouse_eyelid_tem

The first panel is 5 days postnatal in the mouse; the eyelids are still fused. But you can see a difference in the histology of the junctional region (J), and a depression at the arrowhead (you can also see the layers of keratin there). There’s something different in this area.

In the second panel, 10 days postnatally, the depression at the junctional region is deepening and you can see a stratum granulosum (SG) at the seam, while you can also see hair follicles (HF) forming in the adjacent portions of the lid.

The third and fourth panels are at 12 days, and now the keratin layers have extended into the depression from both the inside and outside, completing the separation of the two lids.

Now @jarrydtrokis might be tempted to say that Jesus did the separating, but that’s only true if Jesus is a polypeptide called epidermal growth factor, or EGF. EGF is a molecule that triggers growth and differentiation of keratinocytes, and it turns out that if you treat baby mice with EGF it accelerates the rate of eyelid separation.

I’m sorry, @jarrydtrokis, but your argument from ignorance wasn’t very persuasive, and your talents at ‘research’ are rather pathetic, since the paper describing all that was trivial to find. But then, isn’t this always the case with creationists? There are none so blind as those who will not see.



Findlater GS, McDougall RD, Kaufman MH (1993) Eyelid development, fusion and subsequent reopening in the mouse. J Anat. 183(1):121-9.

Comments

  1. #1 Flo
    March 26, 2013

    It’s kind of sad that it always boils down to “I don’t understand how, therefore god”. It’s really quite pathetic. But at least they make it easy to tear the house of cards down when it actually IS understood how something works.

  2. #2 Nick Theodorakis
    March 26, 2013

    EGF was actually discovered as a factor that would cause premature eyelid opening in newborn mice, to add a historical note.

  3. #3 RK
    WA
    March 26, 2013

    I think that you should look into entering this competition. the $ value may not be worth the time but it would be a lot of fun.
    http://creationsciencehalloffame.org/contests/literal-genesis-trial-contest/

  4. #4 Lee Stocking
    USA
    March 26, 2013

    Actually God made the eyelids of most intelligent designers from foreskins. This explains why they are all a little cockeyed.

  5. #5 Cooper Crumbwell Jr.
    March 26, 2013

    A better question is HOW did God CREATE man from th dust of the earth. Got a “scientific” explanation for that one? I thought not. Better luck next time.

  6. #6 Samantha Thomas
    Nogo, IL
    March 27, 2013

    You say, “There are none so blind as those who will not see.” Maybe their eyelids never opened?

  7. #7 brightmoon
    March 27, 2013

    figures!

  8. #8 Bill
    March 28, 2013

    Cooper, That’s easy, it’s magic. Open your mind. LOL

  9. #9 Serge D.
    March 28, 2013

    I have to say, this is a new one for me too. I guess God of the gaps argument… only problem is, as you have shown, no knowledge gap here… Very weak argument from @jarrydtrokis. At least was interesting to read about eyelid development!

  10. #10 GS test
    http://www.gstest.com/
    April 1, 2013

    The argument from eyelid development – Pharyngula

  11. #11 Ellen
    April 5, 2013

    I don’t see how being able to understand how an eyelid develops means there is no designer any more than NOT being able to understand something means there must be a designer. These arguments are dumb in both directions.

  12. #12 David Marjanović
    Museum für Naturkunde, Berlin
    April 6, 2013

    See comment 9: understanding eyelid development doesn’t prove there’s no designer, but it makes it unnecessary to suppose there is (or was) a designer.