Genetics

Pharyngula

Category archives for Genetics

Optogenetics!

The journal Nature has selected optogenetics as its “Method of the Year”, and it certainly is cool. But what really impressed me is this video, which explains the technique. It doesn’t talk down to the viewer, it doesn’t overhype, it doesn’t rely on telling you how it will cure cancer (it doesn’t), it just explains…

How to afford a big sloppy genome

My direct experience with prokaryotes is sadly limited — while our entire lives and environment are profoundly shaped by the activity of bacteria, we rarely actually see the little guys. The closest I’ve come was some years ago, when I was doing work on grasshopper embryos, and sterile technique was a pressing concern. The work…

The Irish Genome

What a curious paper — it’s fine research, and it’s a useful dollop of data, but it’s simultaneously so 21st century and on the edge of being completely trivial. It’s like a tiny shard of the future whipping by on its way to quaintness. Researchers have for the first time sequenced the genome of an…

Blaschko’s Lines

One of the subjects developmental biologists are interested in is the development of pattern. There are the obvious externally visible patterns — the stripes of a zebra, leopard spots, the ordered ranks of your teeth, etc., etc., etc. — and in fact, just about everything about most multicellular organisms is about pattern. Without it, you’d…

Excellent interview with Craig Venter

Spiegel has a wonderful interview with Venter. The more I hear from Venter, the more I like him; he’s very much a no-BS sort of fellow. He’s the guy who really drove the human genome project to completion, and he’s entirely open about explaining that its medical significance was grossly overstated. SPIEGEL: So the significance…

Most of you don’t understand evolution. I mean this in the most charitable way; there’s a common conceptual model of how evolution occurs that I find everywhere, and that I particularly find common among bright young students who are just getting enthusiastic about biology. Let me give you the Standard Story, the one that I…

Nicholas Wade of the NY Times has written one of those stories that make biologists cringe — it just gets so much wrong. It’s a look back at the human genome project, and I was turned off at the first paragraph. The HGP was badly marketed from the very beginning in the sense that there…

I’ve gotten some email asking for a simplified executive summary of this paper, so here it is. A large study of almost a thousand autistic individuals for genetic variations that make them different from control individuals has found that Autism Spectrum Disorder has many different genetic causes: there isn’t one single gene responsible for ASD,…

Neandertal!

You don’t have to tell me, I know I’m late to the party: the news about the draft Neandertal genome sequence was announced last week, and here I am getting around to it just now. In my defense, I did hastily rewrite one of my presentation to include a long section on the new genome…

It’s a bit late for Mother’s Day, but here are some biological truths about maternal and paternal inheritance. Warning: this is major nerd overload. Wear goggles. The goggles! They do nothing!