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Pharyngula

Evolution, development, and random biological ejaculations from a godless liberal

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PZ Myers is a biologist and associate professor at the University of Minnesota, Morris.
zf_pharyngula.jpg …and this is a pharyngula stage embryo.
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I call Christianity the one great curse, the one great intrinsic depravity, the one great instinct for revenge for which no expedient is sufficiently poisonous, secret, subterranean, petty — I call it the one mortal blemish of mankind.

[Friedrich Nietzsche]

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Neurobiology:

Usher syndrome part IV: Clinical management and research directions

Guest Blogger Danio, one last time: Part I Part II Part III The current standard of pediatric care mandating that all newborns undergo hearing screenings has been applied successfully throughout much of the industrialized world. Early identification of hearing impairments...

Usher syndrome, part III: the plot thickens

Guest Blogger Danio: The time has come to delve into the retinal component of Usher syndrome. In Part II, I briefly described the results of protein localization studies, in which most members of the Usher cohort were found at the...

Usher syndrome, Part II: A complex molecular picture

Guest Blogger Danio: I know, I know. Friday night isn't exactly the best time to smack you with a big messy fistful of science, but PZ will be kicking us Minions out of the house early next week, so I...

Usher syndrome, Part I: an introduction to sensory perception

Guest Blogger Danio: In my introductory post I mentioned that my research focuses on the genetics of hereditary deaf-blindness, specifically Usher syndrome. As it's likely that many of you have never heard of it, I thought I'd kick it up...

It's got a good beat and you can dance to it

My first of several posts about sensory cell neurobiology will be appearing shortly. To get you warmed up, here's a movie showing a mechanosensory hair cell responding to a low frequency sound played through the glass pipette you can...

Evolving proteins in snakes

We've heard the arguments about the relative importance of mutations in cis regulatory regions vs. coding sequences in evolution before — it's the idea that major transitions in evolution were accomplished more by changes in the timing and pattern...

How do you make a cephalopod drool?

We're all familiar with Pavlov's conditioning experiments with dogs. Dogs were treated to an unconditioned stimulus — something to which they would normally respond with a specific behavior, in this case, meat juice which would cause them to drool....

The superior eyes of shrimp

We mammals have been beaten again. Shrimp have more sophisticated eyes than we do, with the ability to see things we can't, and I'm feeling a bit envious....

The subtly different squid eye

By now, everyone must be familiar with the inside out organization of the cephalopod eye relative to ours: they have photoreceptors that face towards the light, while we have photoreceptors that are facing away from the light. There are...

A neurological mechanism for Fragile-X disease

I'm busy preparing my lecture for genetics this morning, in which I'm going to be talking about some chromosomal disorders … and I noticed that this summary of Fragile-X syndrome that was on the old site hadn't made it...

Optical Allusions

Jay Hosler has a new book out, Optical Allusions(amzn/b&n/abe/pwll). If you're familiar with his other books, Clan Apis(amzn/b&n/abe/pwll) and The Sandwalk Adventures(amzn/b&n/abe/pwll), you know what to expect: a comic book that takes its science seriously. Hosler has a fabulous knack...

Buffeted by the winds of chance: why a cell is like a casino

Many of you have already seen the gorgeous video below: it's a spectacularly beautiful animation of the activity in a cell. I like it, and it's a useful illustration, but … there's something fundamental that it gets completely wrong....

A Weird Seizure Drug

A friend of mine, who's name won't be mentioned, blacked out in class the other day. Since then, he's been on a seizure drug. The drug is giving a very weird side effect. It must be affecting his auditory cortex,...

Bisexual flies and the neurochemistry of behavior

On the one hand, this is a strange tale of mutant, bisexual, necrophiliac flies, and you've got to love it for the titillating nature of the experiments. But on the other, much more interesting hand, it's a story about...

Sutdent Report: Zebrafish Again? What Did You Expect?

Wow, it's been a little while since I last blogged. I've been busy trying to stain the eyes of my zebra fish, but still with little luck. My goal is to dye the retinas and their resulting optic nerves and...

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