Reality is always more complicated than you think.
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Jake Young is a MD/PhD student at Mount Sinai School of Medicine in NYC getting a PhD in Behavioral Neuroscience. He holds a BS and MS in Biological Sciences from Stanford University. If a volcano were to erupt Pompei-style in Central Park, his body would be preserved in a scoliotic posture over his lab desk. Archeaologists would later conclude that he spent most of his day training rats to perform tricks, until he went blind building electrical equipment by hand using a dissecting microscope. But, still, he died happy...because science is cool.
Pure Pedantry is a blog about science -- social sciences and otherwise -- as well as academic and scientific culture. No one can live on science alone, so I also like to dwell on pop culture, periodically explore the humanities, and indulge in other types of geeky goodness.
DISCLAIMERS: 1) Jake Young is not a licensed physician (yet). He is merely a medical student. The information published on this site is not intended for use in medical decision-making. Please seek advice from a licensed, medical professional before making any health decisions. 2) The opinions expressed are my own. They do not represent the views of SEED magazine or the educational establishments I currently attend or attended in the past.
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May 19, 2009
Category: Shameless Self Promotion
Hi everyone,
I apologize for my long hiatus from blogging. Things have just been crazy at work lately. All the same it has given me some time to think about what I want from blogging, and where I see myself in the next several years.
For those of you who don't know I am an MD-PhD student which means that when I finish my PhD -- hopefully in about a year -- I will return to medical school. Anyone who has written a dissertation or gone through 3rd of medical school will tell you that neither are particularly conducive to large amounts of free time. So looking forward I have to take into account that finding time for blogging will be more challenging in the future.
Likewise, I have been doing this schtick for three years now, and after over a thousand posts one does begin to struggle for story ideas. I have always been of the opinion that if you are posting something it shouldn't feel like a chore, because if it does what you are writing isn't going to be that interesting. Increasingly, I have to push myself to wake up in the morning and write something.
For these reasons, I have decided to close the Pure Pedantry blog. I know (sigh) we had a good run, but good things come to an end. I have deeply enjoyed writing for all of you as a blogger, and I appreciate all of you that have been my regular readers.
However -- for those of you concerned that I will now vanish off the planet -- I will be continuing to blog for ScienceBlogs in a capacity. Evil Monkey and Scicurious over at Neurotopia have very graciously offered me a job as a co-blogger. While my posting there will be much more irregular than it was here, I will still have a chance to interact with you all. I encourage you to go take a look -- if you haven't already -- at the always interesting conversations that go on at their blog.
In keeping with the aesthetic over at their blog -- and frankly because all the cool kids are doing it these days :) -- I will be adopting the pseudonym NotoriousLTP (but you'll all know it is still me [winks]).
Take care, and I hope to see you all over at Neurotopia.
Yours,
Jake Young
Posted by NotoriousLTP at 10:04 AM • 9 Comments
April 27, 2009
Category: Economics • Genetics • Neuroscience
Razib and I have a discussion up at Bloggingheads.tv about genetics and behavior as well as a brief discussion of neuroeconomics. Check it out below the fold:
Read on »
Posted by NotoriousLTP at 1:06 PM • 3 Comments
April 16, 2009
Category: Neurological disease • Neuroscience • Perception
There is a fascinating case study in Current Biology.
de Gelder et al. discuss a patient -- referred to as TN to protect his privacy -- who had two sequential strokes that damaged his brain. The parts of the brain that were damaged included the primary visual cortex in both hemispheres -- rendering the patient blind. However, the patient could still respond to some visual stimuli through a phenomenon called blindsight.
Even more interesting, the patient could still navigate around visual objects, while reporting being unable to see them and having no memory for what they were.
Read on »
Posted by NotoriousLTP at 6:21 PM • 1 Comments
April 14, 2009
Category: Neuroscience
I don't think I am alone in saying that I often feel a little envy and schadenfreude towards my peers. Science is a particularly competitive business with few remunerative rewards, so a lot of my self-worth is tied to comparisons with my peer's successes and failures. I won't deny being envious when someone gets a Science paper. And while seeing the abject failure of my peers isn't high on my list of priorities, I won't deny the small satisfaction that I get when someone who breezed through their PhD gets taken down a peg.
These aren't happy-joy-joy emotions. They don't make me swell with pride for the future of humanity. They aren't pleasant, but they are nonetheless humane in that -- except for saints -- they are general to the human species.
Takahashi et al. study the neurology of these darker emotions. The authors use fMRI to examine the activation in the human brain that comes when we feel envy and schadenfreude. The authors find that these abstract emotions activate very visceral systems in the brain -- which says interesting things about how the brain is organized.
Read on »
Posted by NotoriousLTP at 5:00 PM • 5 Comments
April 9, 2009
Category: Haha, a funny • Psychology
A study discussed over at Live Science confirms what I have always suspected:
An eight-year study of 218 couples found 90 percent experienced a decrease in marital satisfaction once the first child was born.
"Couples who do not have children also show diminished marital quality over time," says Scott Stanley, research professor of psychology at University of Denver. "However, having a baby accelerates the deterioration, especially seen during periods of adjustment right after the birth of a child."
An unrelated study in 2006 of 13,000 people found parents are more depressed than non-parents. Scientists speculate that the problem is partly a modern one, because parents don't get as much help at home as they did in previous generations.
So your saying that a screaming thing waking you in the middle of the night demanding attention (and possibly financial support) isn't the recipe for nuptial bliss? I'm shocked to hear it.
Reminds me of another Dylan Moran sketch I like. (I really am a hack. Posting two Dylan Moran sketches in a month. It's sad really...)
(Video below the fold. NSFW.)
Read on »
Posted by NotoriousLTP at 4:34 PM • 4 Comments
Category: Neuroscience
The title of this pre-publication paper is, "Evidence on the emergence of the brain's default network from 2-week-old to 2-year-old healthy pediatric subjects." The authors put kids in functional MRIs to measure resting state activity and detect the emergence of the default network.
While I am certain that it is very interesting research, I have a more technical question: minus sedation, how in Heaven's name did they get the kids to sit still long enough to collect the data? An fMRI is hardly a crib decorated with puppies and ducklings. You feel like you are about to be shot out of a torpedo tube, and the whole thing is about as loud as being face first in the speakers at a Kiss concert. How did they get the two years-olds to put up with that?
Ideas?
Posted by NotoriousLTP at 4:13 PM • 5 Comments
April 8, 2009
Category: Parkinson's • Psychology
Neurological diseases can be strange in that they often have additional personality effects. If someone gets a cold, they sneeze a bunch but are basically the same person they were before the cold. In contrast, meningitis can include mental status and personality changes in its early stages -- including irritability and sleepiness. When a disease involves the brain, it can change who we are in addition to making us sick.
In this vein, I found this paper in the journal Brain particularly interesting. Abe et al. report that Parkinson's patients tell fewer lies than controls in a task where they were prompted to do so. In addition, the resting metabolic rate in areas of the brain associated with deception in healthy patients is lower in Parkinson's patients.
The authors argue that -- in addition to the movement difficulties associated with the disease -- Parkinson's may erode other parts of the brain resulting in the lying "deficit." (Whether you consider that a deficit or not is a matter of personal preference.)
Read on »
Posted by NotoriousLTP at 5:05 PM • 4 Comments
March 31, 2009
Category: Ethics • Medical School • Medicine
Nature Clinical Practice Neurology has a salient article on ethics and medicine. The article asks the question: is it ethical to confront an individual with whom you do not have an official doctor-patient relationship, if you think they have a medical problem? Should you or should you not tell them if you see a medical problem?
Neurology is unique among the medical specialties in that much of the clinical examination can be appreciated visually and taught by use of video recordings.3, 4 Since 2003, we have conducted a 'neurological localization course', during which participants are taught correct clinical examination techniques with the help of patients.5 Trainees are often impressed by the wealth of clinical information that can be gleaned by observation alone; for example, how the externally rotated, slightly plantar-flexed attitude of the lower limb of a supine patient can hint at the possibility of an underlying footdrop, or how muscle atrophy, diabetic dermopathy and trophic changes can not only provide clues to an underlying peripheral neuropathy, but can even indicate the level of the stocking paresthesia.
Read on »
Posted by NotoriousLTP at 3:23 PM • 9 Comments
March 29, 2009
Category: Infectious Disease
It's amazing what the kids are up to these days.
This one comes live from Mount Sinai (my present educational residence). Hubner et al., publishing in Science, use an infectious, fluorescent strain of HIV to watch the virus move from one cell to another. Their results are fascinating and may help us develop better ways to treat the disease.
Read on »
Posted by NotoriousLTP at 9:10 PM • 7 Comments
March 27, 2009
Category: Sex
What you think about during sex matters.
A guy who doesn't want to, ahem, proceed too quickly will think of baseball or something non-sex related. A girl who wants to proceed more quickly might focus on surrounding milieu of a loving environment. These are stereotypes, I know, but the fact that we have them does confirm that what we think about during sex matters: what we attend to changes the nature of the experience.
In this vein, Mind Hacks links to a great review of the role of attention in sex. Vaughan makes the point that we tend to view sexual dysfunction as a problem of equipment -- hence prescribing Viagra, when a more accurate diagnosis may be a problem of state-of-mind. Definitely read the whole thing.
It reminds me a funny sketch by one of my favorite comics, Dylan Moran (below the fold):
Read on »
Posted by NotoriousLTP at 12:43 PM • 3 Comments