Alzheimer's

Pure Pedantry

Category archives for Alzheimer’s

Alzheimer’s research is an ongoing field. Although we know a lot more than we used to, we still don’t entirely understand why the accumulation of proteins in Alzheimer’s disease kills neurons or renders them non-functional. One intriguing part of the explanation may be offered by Varvel et al. who show that the active proteins in…

Here is an interesting approach to fighting Alzheimer’s disease: use adjuvants to activate microglia in the nasal cavity. Frenkel et al. publishing the Annals of Neurology show that the administration of an adjuvant called Protollin into the nasal cavity of both young and old mice transgenically engineered to get Alzheimer’s disease can reduce the plaque…

One of the more common questions I get is why they haven’t found any drugs to treat Alzheimer’s disease. (But they have, haven’t they? What about cholinesterase inhibitors like Aricept? Ed. Those drugs mask the symptoms of Alzheimer’s disease, but they do not change the clinical course.) Drug companies are particularly gifted at finding molecules…

This paper was covered by CNN last week, and I didn’t have a chance to talk about it then. It is a case study by Tobinick and Gross in the Journal of Neuroinflammation where a patient with Alzheimer’s disease (AD) injected intrathecally (into their spinal fluid) with a TNF-alpha antagonist called etanercept showed rapid and…

You look away from a field for two seconds, and they get all crazy on you… I used to do only molecular biology focusing primarily on neurodegenerative diseases like Alzheimer’s. Since I moved to a lab that studies behavior, I haven’t been keeping up with the literature of Alzheimer’s as much as I should so…

We all know that inhaled anesthesia is over the short-term impairs neurological function; that is sort of the point using it for surgery. However, a debate exists about whether inhaled anesthetics have long-term neurological consequences as well. In light of that debate Bianchi et al, publishing in the journal Neurobiology of Aging, have shown that…