Synapses

Pure Pedantry

Category archives for Synapses

Videos of AMPA-R Insertion

One of the mechanisms — perhaps even the primary mechanism — by which synapses in the brain are potentiated — made more sensitive to activation — is the insertion of more AMPA receptors (AMPA-R) into the synapse. AMPA-R are glutamate-activated, cation (Na and Ca) channels that are really the business end of creating the electrical…

Cool Pictures of the Presynapse

Synaptic transmission is incredibly fast. For example at the neuromuscular junction, the minimum time between the appearance of the electrical activity in the axon terminal and the appearance of electrical activity in the muscle as little as .4-.5 ms. How is this managed? One of the ways is that the vesicles that contain neurotransmitters are…

Presynaptic Vesicles are Hemifused

There has always been a bit of a debate as to whether the vesicles in the presynaptic nerve terminal that contain transmitter are just near the presynaptic membrane or are in fact hemifused with it. At the presynapse, vesicles containing neurotransmitter are prepared and aligned by the presynaptic membrane — the process of synaptic release…