integrins

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Category archives for integrins

On Mimicking Phosphotyrosine

When doing science, there’s generally one totally optimal way of performing an experiment. But, there may also be several other less optimal means of gathering similar data, and one of those may be much more feasible than the totally optimal method. As a scientist, you have to determine whether this other method is sufficient, or…

Two New Papers on Integrin Activation

Just as I was in the process of finishing my doctorate in August, I found out that my first first-author paper had been accepted for publication by The EMBO Journal. This was good news, because we were reporting some pretty fundamental findings in a relatively saturated field, and one of our competitors had managed to…

Fine-Tuning Cell Adhesiveness

Cells in higher organisms exist in a dynamic environment, requiring the ability to alternately grasp and disengage from the three-dimensional web of their surroundings. One family of proteins in particular, the integrins, plays a key role in this process by acting as the hands of the cell. Spanning the cell membrane, they link the extracellular…

The New York Times reported yesterday that “scientists find new receptor for HIV,” referring to a paper published online in Nature Immunology on Sunday by Arthos et al. This is basically correct, although it would be more accurate to call the new receptor a co-receptor, since the infection of a cell with HIV still depends…

An individual cell inside the human body is in a dynamic environment: it not only has to anchor itself to its surroundings but also be able to communicate with them and respond as appropriate. One group of proteins–the integrins–play a central role in all of these tasks. The integrins are large (about 200,000 Da) membrane-spanning…

Congratulations to Daniel Rhoads

Via A Blog Around the Clock comes news that Daniel Rhoads, who writes the informative blog Migrations (and formerly A Concerned Scientist), has successfully defended his dissertation. So, after a few minor revisions, it looks like it won’t be too long before we’ll have to call him Dr. Rhoads. In good blogger form, Daniel has…