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All scientific laboratories are not created equal, a fact evident in the differences in regulations and expectations between large research centers and smaller-scale labs. As Mike the Mad Biologist explains, large genomics labs in particular are subject to productivity standards, such as the swift publicization of genomic sequence data, that smaller labs are not forced to comply with, largely due to the sources of their funding—large centers often operate on federal contract rather than grant money. Is this dichotomy fair to large genomics centers? Mike explains why it might be necessary, and Dan MacArthur of Genetic Future has more.