roche

"Some prophecies are self-fulfilling But I've had to work for all of mine Better times will come to me, God willing Cause I can't leave this world behind" -Josh Ritter You sure can't leave this world behind. At least, not very easily. The reason for it, of course, is gravity. Image Credit: Physclips, via the University of New South Wales' School of Physics. Here on the surface of the Earth, the gravitational potential well is pretty large; large enough that there's no easy way off. Sure, you can pour a huge amount of energy into a rocket to try and overcome this gravitational potential…
A critical aspect of both evidence-based medicine (EBM) and science-based medicine (SBM) is the randomized clinical trial. Ideally, particularly for conditions with a large subjective component in symptomatology, the trial should be randomized, double-blind, and placebo-controlled. As Kimball Atwood pointed out just last week (me too), in EBM, scientific prior probability tends to be discounted while in SBM it is not, particularly for therapies that are wildly improbable strictly on the basis of basic science, but for both the randomized clinical trial remains, in essence, where the "rubber…
You've never heard "in real time" screamed with so much passion. Not just one, but two big-haired metal-band bio-rock videos after the fold. . . (sources: here and here)