Terra Sigillata

Archives for May, 2007

For five decades, the Biological Sciences Curriculum Study (BSCS) has been an national resource for science education and teacher development in the somewhat unlikely setting of Colorado Springs, Colorado. In addition to a variety of print resources, often developed with NSF support. Among their greatest personal resources for teachers is the Keys to Science Institutes…

While the blogosphere buzz is the potential anti-obesity therapy put forth by Ron Evans’ group to turn on PPAR-delta, I was reminded of shortcomings in our nation’s drug distribution system from the FDA Medwatch program. (I’ve written about this topic before here and here.). The latest alert regards a mix-up of weight loss drugs: MedWatch…

Today’s edition of the NCI Cancer Bulletin features another natural product clinical trial, this time for depsipeptide in T-cell lymphoma. Depsipeptide (Romidepsin or FR901228) is an early histone deacetylase inhibitor isolated from fermentation of Chromobacterium violaceum. Several histone deacetylase inhibitors are in clinical trials for various cancers and many are derived from natural products. However,…

A few weeks ago, I commented on the increased action by the US FDA against unapproved drugs that have been used for decades but were never subjected to today’s formal framework of preclinical and clinical safety and efficacy trials (most recent action here). Over the last couple of months, FDA has been creating a bit…