Terra Sigillata

The Japanese scientist who grew fascinated by fungi as a boy is one among five of this years’ recipients of a Lasker Award. Endo was specifically given the Lasker~DeBakey Clinical Medical Research Award.

Dr Akira Endo first isolated the hypocholesterolemic compound, mevastatin or compactin, from Penicillium citrinum. Compactin was the forerunner to the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reducatase) inhibitors. This fungal natural product gave rise to the cholesterol-lowering “statin” drugs. While not without risk of adverse events, this drug class is widely considered life-saving (although some work suggests that while heart attack frequency is reduced, overall mortality may not be.).

Dr Endo’s story has long influenced my career and even showed up as I started this blog.

Congratulations, Dr Endo! I am not being melodramatic when I say that your commitment to the wonders of medicines from the earth has been a true benefit to mankind.

Update: The Lasker Foundation site has posted a link to a lovely and colorful essay by Dr Endo in the October 2008 issue of Nature Medicine, “A gift from nature: the birth of the statins” (PDF here) – get it while it’s still free-access.

Comments

  1. #1 N.B.
    September 15, 2008

    Woo! Statins! One of those “evil pharma synthetic” drugs that so many people don’t seem to realize has totally “natural” roots.

    I must concur that Dr. Endo’s achievement is quite spectacular, and I’m glad to see that he’s being recognized for it.

  2. #2 leigh
    September 16, 2008

    that was indeed a fantastic achievement, i am glad to see it recognized. i wish more people knew the backstory about some of these compounds derived from natural origins. i sat in my college intro pharm class in absolute awe as i listened to this and other stories, and knew then that i was going to graduate school to become a pharmacologist.

  3. #3 Scotty B
    September 16, 2008

    Congrats to Dr Akira Endo!

  4. #4 ultrasound gel
    September 17, 2008

    Woo! Congrats

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