Research

Terra Sigillata

Category archives for Research

A couple of colleagues turned me on the other morning to a press release by researchers at the University of Warwick who recently published in PNAS that their data apparently overturns the Meyer-Overton Rule regarding solubility of a compound in olive oil and its propensity for crossing biological membranes. I’m having trouble understanding exactly why…

CORRECTION: The following was to be a part-sincere/part-serious sendup of my buddy Bora’s penchant for monitoring the entire Internet. Bora did indeed host the first edition of Praxis, the new blog carnival of academic life. However. The Praxis experimental carnival of “the experience of living the scientific” was established, founded, and otherwise continues to be…

Most people know of methadone as a long-term substitution therapy for people addicted to heroin, morphine, or other similar drugs called opiates or opioids. A good, free full-text description of methadone maintenance therapy (MMT) can be found in the 15 June 2001 issue of American Family Physician. Now, in the 1 August 2008 issue of…

This morning our dear friend and colleague whose wine escapades often fill this spot awoke to the rewards of retirement. My senior cancer research colleague, Erleichda, has just closed the book on 30 years with a single pharmaceutical company, unheard of in today’s climate of layoffs and jumping from one company to the next. My…

Unlike the blogosphere and some unhinged stakeholders, I’ve been quietly watching the PZ Myers crackergate episode unfold. My concerns have been less theological than educational, primarily because I am the beneficiary of an arm of the University of Florida public higher education system. I’ve been beating my head against the wall as to why the…

Arachnologist and diplopodologist Dr Jason E Bond at East Carolina University in Greenville, NC, is most recently well-known for naming a spider (Myrmekiaphila neilyoungi) after Rock and Roll Hall of Famer, Neil Young. Kristin Day of The Daily Reflector is now reporting that Professor Bond has agreed to name a spider after Stephen Colbert, Comedy…

This one’s for the molecular and cell biology and pharmaceutical chemistry crowd: what’s on your current wishlist? If you had a US$250,000 equipment budget, what would you buy to outfit the lab? Assume that your department has all the big ticket items like real-time PCR, confocal microscopy, flow cytometer, histology gadgetry, >500MHz NMR, MALDI-TOF, LCs,…

I’m not sure whether this story qualifies as alternative medicine or religion, or neither. I throw it out to you because I and other sci/med bloggers widely criticize the infiltration of so-called alternative medicine in our academic medical centers. But here in today’s Health Journal section of the Wall Street Journal, Melinda Beck tells us…

Actinomycin D was the first antitumor antibiotic isolated from Streptomyces parvallus cultures by the lab of 1952 Nobel laureate, Dr Selman Waksman, at Rutgers University. However, it took a young Chinese physician and the confidence in her by a future US Surgeon General for this natural product drug to positively impact the lives of children…

A paper in last month’s issue of Nature Reviews Drug Discovery reported that US drug approvals during 2007 were the lowest number since 1983. (17 new molecular entities and 2 biologicals; see this figure for 1996-2007 data.) The review cites increased regulatory action as a factor in this reduction, especially following high-profile post-marketing safety issues…